drugset / Trial / NCT03030911
Dexmedetomidine vs Midazolam on Resting Energy Expenditure in Critically Ill Patients
RandomizedParallel-groupTriple-blindTreatment
Summary
The aim of this study is to compare the effect of dexmedetomidine on resting energy expenditure in relation to the midazolam in critically ill patients using indirect calorimetry
Timeline
- Start
- 2017-01-01
- Primary completion
- 2018-03-10
- Completion
- 2018-03-15
Publications
- Background Walker RN, Heuberger RA. Predictive equations for energy needs for the critically ill. Respir Care. 2009 Apr;54(4):509-21.
- Background Rubinson L, Diette GB, Song X, Brower RG, Krishnan JA. Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit. Crit Care Med. 2004 Feb;32(2):350-7. doi: 10.1097/01.CCM.0000089641.06306.68.
- Background Covelli HD, Black JW, Olsen MS, Beekman JF. Respiratory failure precipitated by high carbohydrate loads. Ann Intern Med. 1981 Nov;95(5):579-81. doi: 10.7326/0003-4819-95-5-579.
- Background Fung EB. Estimating energy expenditure in critically ill adults and children. AACN Clin Issues. 2000 Nov;11(4):480-97. doi: 10.1097/00044067-200011000-00002.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.75 ug/kg | — |
| Comparator | Midazolam | Small molecule | 5 mg | — |
| Comparator | Fentanyl | Other / unclassified | 1 ug/kg | — |
Indications
No indication recorded.