Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
Summary
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence. A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR). Investigators will also use this data, and publicly available data to complete agent-based modeling for comparative and cost-effectiveness of various TB screening and treatment strategies among prisoners.
Timeline
- Start
- 2017-08-21
- Primary completion
- 2024-04-04
- Completion
- 2024-04-04
Outcome
Missed primary endpoint
registry analysis (superiority test); Standard Isoniazid (INH) for 26 Weeks vs Short-course Isoniazid + Rifapentine (INH + RIF) for 12 Weeks; p = 0.08; t-test, 2 sided NCT03089983 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Isoniazid | Small molecule | — | — |
| Subject | Rifapentine | Small molecule | — | — |