drugset / Trial / NCT03089983
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
Completed
316 enrolled
Yale University
National Institute on Drug Abuse (NIDA) · collabUniversity of Malaya · collab
RandomizedParallel-groupOpen-labelHealth-services research
Summary
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence. A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR). Investigators will also use this data, and publicly available data to complete agent-based modeling for comparative and cost-effectiveness of various TB screening and treatment strategies among prisoners.
Timeline
- Start
- 2017-08-21
- Primary completion
- 2024-04-04
- Completion
- 2024-04-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Isoniazid | Small molecule | — | — |
| Subject | Rifapentine | Small molecule | — | — |