drugset / Trial / NCT03120715

Pregnancy Outcome of Women Using Low Molecular Weight Heparin Before Frozen-thawed Embryo Transfer

NCT03120715

Phase 4 Unknown 342 enrolled Nanfang Hospital, Southern Medical University
RandomizedParallel-groupOpen-labelTreatment

Summary

Embryo freezing is a technique used commonly to optimize the pregnancy rate in assisted reproduction techniques (ART). Hormone replacement therapy (HRT) regimen is applied to prepare endometrium for frozen embryo transfer (FET) commonly.At present, It is unclear whether preimplantation low molecular weight heparin (LMWH) improves live birth and pregnancy rates in subfertile women undergoing FET. The study is a prospective randomized controlled trial to compare the pregnancy outcomes of FET in hormonal replacement therapy(HRT) cycles with or without LMWH administration before implantation.

Timeline

Start
2016-07-01
Primary completion
2017-06-30
Completion
2017-09-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Heparin Other / unclassified 4100 iu Subcutaneous
Background Progesterone Other / unclassified 60 mg Intramuscular
Background conjugated estrogens Other / unclassified 6 mg Oral
Background hCG Unknown 10000 iu Intramuscular

Indications