drugset / Trial / NCT03120715
Pregnancy Outcome of Women Using Low Molecular Weight Heparin Before Frozen-thawed Embryo Transfer
RandomizedParallel-groupOpen-labelTreatment
Summary
Embryo freezing is a technique used commonly to optimize the pregnancy rate in assisted reproduction techniques (ART). Hormone replacement therapy (HRT) regimen is applied to prepare endometrium for frozen embryo transfer (FET) commonly.At present, It is unclear whether preimplantation low molecular weight heparin (LMWH) improves live birth and pregnancy rates in subfertile women undergoing FET. The study is a prospective randomized controlled trial to compare the pregnancy outcomes of FET in hormonal replacement therapy(HRT) cycles with or without LMWH administration before implantation.
Timeline
- Start
- 2016-07-01
- Primary completion
- 2017-06-30
- Completion
- 2017-09-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Heparin | Other / unclassified | 4100 iu | Subcutaneous |
| Background | Progesterone | Other / unclassified | 60 mg | Intramuscular |
| Background | conjugated estrogens | Other / unclassified | 6 mg | Oral |
| Background | hCG | Unknown | 10000 iu | Intramuscular |