Intraoperative Protective Ventilation for Obese Patients Undergoing Gynaecological Laparoscopic Surgery

Completed 60 enrolled Catholic University of the Sacred Heart

RandomizedParallel-groupOpen-labelTreatment

Summary

Background. The use of a comprehensive strategy providing low tidal volumes, peep and recruiting maneuvers in patients undergoing open abdominal surgery improves postoperative respiratory function and clinical outcome. It is unknown whether such ventilatory approach may be feasible and/or beneficial in patients undergoing laparoscopy, as pneumoperitoneum and Trendelenburg position may alter lung volumes and chest-wall elastance. Objective. The investigators designed a randomized, controlled trial to assess the effect of a lung-protective ventilation strategy on postoperative oxygenation in obese patients undergoing laparoscopic surgery.

Timeline

Start: 2017-05-01
Primary completion: 2019-03-31
Completion: 2019-03-31

Publications

Grieco DL, Russo A, Anzellotti GM, Romano B, Bongiovanni F, Dell'Anna AM, Mauti L, Cascarano L, Gallotta V, Rosa T, Varone F, Menga LS, Polidori L, D'Indinosante M, Cappuccio S, Galletta C, Tortorella L, Costantini B, Gueli Alletti S, Sollazzi L, Scambia G, Antonelli M. Lung-protective ventilation during Trendelenburg pneumoperitoneum surgery: A randomized clinical trial. J Clin Anesth. 2023 May;85:111037. doi: 10.1016/j.jclinane.2022.111037. Epub 2022 Dec 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Fentanyl	Other / unclassified	0.6 ug/kg	Intravenous
Background	Fentanyl	Other / unclassified	0.8 ug/kg	Intravenous
Background	Propofol	Small molecule	2 mg/kg	Intravenous
Background	Propofol	Small molecule	3 mg/kg	Intravenous
Background	Rocuronium	Other / unclassified	0.9 mg/kg	Intravenous
Background	Rocuronium	Other / unclassified	1.2 mg/kg	Intravenous

Indications

No indication recorded.