Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery

Completed 45 enrolled Mirna Abraham-Nordling

RandomizedParallel-groupOpen-labelTreatment

Summary

A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel movement in patients with low anterior resection syndrome.

Timeline

Start: 2017-05-15
Primary completion: 2022-12-01
Completion: 2022-12-01

Publications

Background Pieniowski EHA, Bergstrom CM, Nordenvall CAM, Westberg KS, Johar AM, Tumlin Ekelund SF, Larsson KR, Pekkari KJ, Jansson Palmer GC, Lagergren P, Abraham-Nordling M. A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery. Ann Surg. 2023 Jan 1;277(1):30-37. doi: 10.1097/SLA.0000000000005482. Epub 2022 Jul 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Loperamide	Small molecule	—	—
Comparator	Sorbitol	Small molecule	—	—
Comparator	Sterculia gum	Unknown	—	—

Indications

No indication recorded.