Drugs / Sorbitol
Sorbitol
also known as
D-sorbitol · 7B5697N · D-glucitol · D-glucitol syrup · E 420 · E-420(i) · FEMA NO. 3029 · Glucitol, d- · +8 more
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | SORBITOL-MANNITOL | — | 1971-08-20 | fda.gov ↗ |
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT06826079 | Nov 2024 → Aug 2026 overdue | gastric cancer, gastroesophageal junction adenocarcinoma | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Recruiting | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT05092841 | Sep 2021 → Mar 2024 | Charcot-Marie-Tooth disease type 1A | Tasly GeneNet Pharmaceuticals Co., Ltd | Completed | No outcome recorded |
| Phase 3 | NCT04762758 | Mar 2021 → Apr 2024 | Charcot-Marie-Tooth disease | Pharnext S.C.A. | Unknown | No outcome recorded |
| Phase 3 | NCT01474499 | Sep 2011 → Mar 2012 | constipation disorder | Ferring Pharmaceuticals | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT01879605 | Dec 2007 → Dec 2009 | constipation disorder, ileus | Oslo University Hospital | Completed | No outcome recorded |
| Comparator or background therapy4 trials | ||||||
| Phase 1 | NCT05320094 Background | Apr → Sep 2022 | — | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1/2 | NCT00374881 Comparator | Sep 2006 → Jun 2007 | — | BioLineRx, Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT02579759 Comparator | Dec 2015 → Mar 2018 | Charcot-Marie-Tooth disease type 1A | Pharnext S.C.A. | Completed | No outcome recorded |
| — | NCT03215017 Comparator | May 2017 → Dec 2022 | — | Mirna Abraham-Nordling | Completed | No outcome recorded |
Evidence & citations 19 cited values
Every value below carries the sentence it was read from. 10 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Sorbitol | “Combination of (RS)-baclofen, naltrexone hydrochloride and D-sorbitol, termed PXT3003, improved myelination in the Pmp22 transgenic co-culture cellular model, and moderately...” PMID 25491744 ↗ Dec 20146“Medication to help control of the bowel movement (One or a combination of Loperamide, Sorbitol, Sterculia gum)” NCT03215017 ↗ |
| Known as | 7B5697N | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | D-glucitol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | D-glucitol syrup | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | D-sorbitol | “Combination of (RS)-baclofen, naltrexone hydrochloride and D-sorbitol, termed PXT3003, improved myelination in the Pmp22 transgenic co-culture cellular model, and moderately...” PMID 25491744 ↗ Dec 20142“(RS)-baclofen, naltrexone hydrochloride and D-sorbitol oral fixed dose combination” NCT05092841 ↗ |
| Known as | E 420 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | E-420(i) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | FEMA NO. 3029 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Glucitol, d- | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Ins no.420(i) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Ins-420(i) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Isomalt impurity, sorbitol- | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Neosorb p 60w | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | NSC-25944 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Sorbitol (e420) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Sorbitol component of -mannitol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Known as | Sorbitol solutions | ChEMBL registry synonym — accepted as the source's own label CHEMBL1682 ↗ |
| Modality | Small molecule | — CHEMBL1682 ↗ |
| Route | Oral | “A Randomized, Double-Blind, Single-Center, 5 Way Cross-Over Study to Assess the Effect of Adding Oral Phenylephrine and Oral Sorbitol to Low Dose (1.5 mg) Plain Oral Morphine...” NCT00374881 ↗ |