A Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Single-dose of Mavacamten in Healthy Participants

NCT05320094 ↗

Phase 1 Completed 45 enrolled Bristol-Myers Squibb

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the effects of co-administration of activated charcoal with sorbitol on the single-dose drug levels of mavacamten in healthy participants.

Timeline

Start: 2022-04-15
Primary completion: 2022-09-11
Completion: 2022-09-11

Publications

Merali S, Chiang M, Sychterz C, Chao L, Simmons T, Xu Y, Zhao A, Attanasio M, Murthy B, Perera V. Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants. Am J Cardiovasc Drugs. 2024 Jul;24(4):569-575. doi: 10.1007/s40256-024-00659-z. Epub 2024 Jun 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Activated Charcoal	Other / unclassified	50 g	—
Subject	Mavacamten	Small molecule	15 mg	—
Background	Sorbitol	Small molecule	—	—

Indications

No indication recorded.