drugset / Trial / NCT03240055
The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness
RandomizedParallel-groupTriple-blindOther
Summary
The purpose of this study is to investigate the effect of spinal anesthesia on ED50 and BIS50 of etomidate for the loss of consciousness (LOC) by using up-and-down method.The hypothesis was that spinal anesthesia could significantly reduce the etomidate bolus dose for the LOC and could also achieve hemodynamic stability during anesthesia induction.
Timeline
- Start
- 2017-06-01
- Primary completion
- 2017-07-15
- Completion
- 2017-07-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupivacaine | Other / unclassified | 3 ml | Intrathecal |
| Subject | Etomidate | Small molecule | 0.089 mg/kg | Intravenous |
| Subject | Etomidate | Small molecule | 0.105 mg/kg | Intravenous |
Indications
No indication recorded.