Etomidate

also known as Amidate · Etomidato · Hypnomidate · NSC-759160

Developed for: coronary artery disorder · respiratory failure · infectious disease with sepsis · acute respiratory failure
Investigated by: Henan Provincial People's Hospital · Advocate Hospital System · Jiangsu Nhwa Pharmaceutical Co., Ltd. · RenJi Hospital · University of Texas Southwestern Medical Center · Ailin Luo
+26 more
· Air Force Military Medical University, China · Cheju Halla General Hospital · Du yi · Emergency Medicine Foundation · Erasme University Hospital · General Hospital of Ningxia Medical University · Hartford Hospital · Insel Gruppe AG, University Hospital Bern · Korea University Anam Hospital · Maharashtra University of Health Sciences · Military Institute od Medicine National Research Institute · Northern Jiangsu People's Hospital · Peking University Third Hospital · Second Hospital of Shanxi Medical University · Shaanxi Provincial People's Hospital · Sichuan Haisco Pharmaceutical Group Co., Ltd · St. Luke's Hospital, Pennsylvania · Third Affiliated Hospital of Zhengzhou University · Tianjin Medical University General Hospital · Tongji Hospital · University Hospital of Saint-Etienne · University of California, Davis · Xijing Hospital · Yeongseok Yun · Zhihong LU · Zhujiang Hospital

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	AMIDATE	—	1982-09-07	fda.gov ↗

Trials 37

today

US approved 1982

NCT07079176 · not/applicable NCT07012902 · Ph 0 NCT06976996 · not/applicable NCT07019246 · not/applicable NCT06068764 · Ph 4 NCT05810363 · not/applicable NCT06664138 · Ph 4 NCT05259787 · Ph 4 NCT05358535 · Ph 3 NCT05520645 · not/applicable NCT05407870 · not/applicable NCT04369014 · not/applicable NCT05862753 · not/applicable NCT05223907 · Ph 4 NCT03820388 · Ph 4 NCT02910206 · not/applicable NCT03240055 · not/applicable NCT04054063 · Ph 1 NCT02643381 · Ph 4 NCT02644980 · Ph 4 NCT02711917 · not/applicable NCT02147678 · Ph 4 NCT02182648 · Ph 4 NCT02174120 · Ph 4 NCT02208596 · Ph 4 NCT02202239 · Ph 4 NCT02013986 · Ph 4 NCT01913054 · Ph 4 NCT02027311 · Ph 4 NCT01729897 · not/applicable NCT02807610 · Ph 4 NCT01930019 · not/applicable NCT00441792 · not/applicable NCT00451776 · Ph 4 NCT00415701 · Ph 4 NCT00248729 · Ph 2

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Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT07012902	Jun 2025 overdue	—	Second Hospital of Shanxi Medical University	Not yet recruiting	No outcome recorded
Phase 11 trial
Phase 1	NCT04054063	Nov → Dec 2016	—	Sichuan Haisco Pharmaceutical Group Co., Ltd	Completed	No outcome recorded
Phase 21 trial
Phase 2	NCT00248729	Oct 2002 → Nov 2005	respiratory failure	St. Luke's Hospital, Pennsylvania	Completed	No outcome recorded
Phase 31 trial
Phase 3	NCT05358535	Sep 2022 → Jan 2027 expected	—	University of Texas Southwestern Medical Center	Recruiting	No outcome recorded
Phase 418 trials · 1 missed
Phase 4	NCT06068764	Dec 2023 → Dec 2025 overdue	coronary artery disorder	Hartford Hospital	Recruiting	No outcome recorded
Phase 4	NCT06664138	Apr 2023 → Jan 2024	bipolar disorder, major depressive disorder, schizoaffective disorder, schizophrenia	Yeongseok Yun	Completed	No outcome recorded
Phase 4	NCT05259787	Sep 2022 → Dec 2023	—	RenJi Hospital	Completed	No outcome recorded
Phase 4	NCT05223907	May 2021 → Dec 2022	—	Henan Provincial People's Hospital	Completed	No outcome recorded
Phase 4	NCT03820388	Dec 2017 → Jul 2018	—	University of California, Davis	Completed	No outcome recorded
Phase 4	NCT02643381	Jun 2016 → Dec 2020	cardiac arrest, respiratory failure	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 4	NCT02644980	Dec 2015 → Aug 2016	delirium	Xijing Hospital	Unknown	No outcome recorded
Phase 4	NCT02147678	Dec 2014 → Feb 2015	—	Shaanxi Provincial People's Hospital	Unknown	No outcome recorded
Phase 4	NCT02182648	Oct 2014 → May 2015	—	Henan Provincial People's Hospital	Unknown	No outcome recorded
Phase 4	NCT02174120	Oct 2014 → Sep 2015	—	Henan Provincial People's Hospital	Unknown	No outcome recorded
Phase 4	NCT02208596	Sep 2014 → Feb 2015	—	Third Affiliated Hospital of Zhengzhou University	Unknown	No outcome recorded
Phase 4	NCT02202239	Sep 2014 → Aug 2015	—	Zhujiang Hospital	Unknown	No outcome recorded
Phase 4	NCT02013986	Sep 2013 → Jun 2014	bile duct cyst, congenital hydronephrosis	Du yi	Unknown	No outcome recorded
Phase 4	NCT01913054	Aug → Dec 2013	—	Jiangsu Nhwa Pharmaceutical Co., Ltd.	Unknown	No outcome recorded
Phase 4	NCT02027311	Apr → Aug 2013	cholangiocarcinoma, choledocholithiasis, malignant pancreatic neoplasm, pancreatitis	Cheju Halla General Hospital	Completed	Missed primary
Phase 4	NCT02807610	Mar 2011 → Apr 2013	—	Maharashtra University of Health Sciences	Completed	No outcome recorded
Phase 4	NCT00451776	Jun 2007 → Oct 2008	—	University Hospital of Saint-Etienne	Completed	No outcome recorded
Phase 4	NCT00415701	Nov 2006 → Dec 2009	coronary artery disorder, mitral valve insufficiency	Insel Gruppe AG, University Hospital Bern	Completed	No outcome recorded

Phase not applicable15 trials · 1 met primary · 1 missed
—	NCT07079176	Aug 2025 → Aug 2027 expected	—	RenJi Hospital	Not yet recruiting	No outcome recorded
—	NCT06976996	Mar → Dec 2025 overdue	—	Northern Jiangsu People's Hospital	Active not recruiting	No outcome recorded
—	NCT07019246	Feb 2025 → May 2026 overdue	hypertensive disorder	Tongji Hospital	Recruiting	No outcome recorded
—	NCT05810363	Jun 2023 → Jun 2024	acute hypotension	Ailin Luo	Completed	No outcome recorded
—	NCT05520645	Aug 2022 → Sep 2023	—	Peking University Third Hospital	Unknown	No outcome recorded
—	NCT05407870	Jun → Nov 2022	—	Korea University Anam Hospital	Completed	No outcome recorded
—	NCT04369014	Feb → Dec 2022	—	Air Force Military Medical University, China	Unknown	No outcome recorded
—	NCT05862753	Jan → Apr 2022	—	Erasme University Hospital	Completed	No outcome recorded
—	NCT02910206	Aug 2017 → Nov 2019	—	Zhihong LU	Completed	Met primary
—	NCT03240055	Jun → Jul 2017	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT02711917	Jul → Dec 2015	—	Tianjin Medical University General Hospital	Completed	No outcome recorded
—	NCT01729897	May → Aug 2012	postgastrectomy syndrome	Jiangsu Nhwa Pharmaceutical Co., Ltd.	Completed	No outcome recorded
—	NCT01930019	Jun 2009 → Jul 2011	obesity disorder	Military Institute od Medicine National Research Institute	Completed	No outcome recorded
—	NCT00441792	Oct 2007 → Dec 2010	infectious disease with sepsis	Advocate Hospital System	Completed	Missed primary
—	NCT00938990	—	—	Advocate Hospital System	Withdrawn	No outcome recorded

Comparator or background therapy42 trials
Phase 1	NCT07474545 Comparator	Mar 2026 → Dec 2027 expected	—	Hunan Kelun Pharmaceutical Co., Ltd.	Recruiting	No outcome recorded
Phase 2	NCT06682546 Comparator	Nov → Dec 2024	—	Ahon Pharmaceutical Co., Ltd.	Completed	No outcome recorded
Phase 2/3	NCT02105415 Comparator	Apr 2014 → Nov 2017	—	Mayo Clinic	Completed	Missed primary
Phase 3	NCT06858852 Comparator	Mar → Dec 2025 overdue	—	Ahon Pharmaceutical Co., Ltd.	Not yet recruiting	No outcome recorded
Phase 3	NCT02822144 Background	Sep 2016 → Aug 2020	stroke disorder	Rennes University Hospital	Completed	No outcome recorded
Phase 3	NCT01248234 Comparator	Jul 2012	hypertensive disorder	University of Mississippi Medical Center	Withdrawn	No outcome recorded
Phase 4	NCT05277896 Comparator	Apr 2022 → Sep 2025	acute respiratory failure	Vanderbilt University Medical Center	Completed	No outcome recorded
Phase 4	NCT04934683 Comparator	Jul 2021 → Dec 2026 expected	—	The University of Texas Health Science Center, Houston	Enrolling by invitation	No outcome recorded
Phase 4	NCT03263117 Comparator	Jul 2018 → Apr 2023	stroke disorder	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 4	NCT03625076 Comparator	Jun 2018 → May 2020	—	Kendall Healthcare Group, Ltd.	Unknown	No outcome recorded
Phase 4	NCT03545503 Comparator	Jan 2018 → Sep 2019	—	South East Area Health Education Center, Wilmington, NC	Completed	No outcome recorded
Phase 4	NCT02500225 Comparator	Jan → Feb 2017	—	Inonu University	Completed	No outcome recorded
Phase 4	NCT02924090 Comparator	Sep 2016 → Dec 2017	depressive disorder	University of Manitoba	Unknown	No outcome recorded
Phase 4	NCT02727712 Background	Apr → Sep 2016	coronary artery disorder	Xiangya Hospital of Central South University	Unknown	No outcome recorded
Phase 4	NCT02518789 Background	Sep 2015 → Aug 2016	—	Tang-Du Hospital	Unknown	No outcome recorded
Phase 4	NCT02289391 Background	Dec 2014 → Dec 2015	asthma	Second Affiliated Hospital of Xi'an Jiaotong University	Unknown	No outcome recorded
Phase 4	NCT02224443 Background	Sep 2014 → Aug 2015	—	First Affiliated Hospital Xi'an Jiaotong University	Unknown	No outcome recorded
Phase 4	NCT02134093 Background	Jul 2014 → May 2015	—	Tang-Du Hospital	Unknown	No outcome recorded
Phase 4	NCT02154074 Background	May → Oct 2014	post-surgical hypoinsulinemia	Second Affiliated Hospital of Xi'an Jiaotong University	Unknown	No outcome recorded
Phase 4	NCT02186990 Comparator	May → Aug 2014	—	Ordu University	Completed	No outcome recorded
Phase 4	NCT02141737 Background	May → Oct 2014	—	Tang-Du Hospital	Unknown	No outcome recorded
Phase 4	NCT01823328 Comparator	Sep 2013 → Oct 2015	—	Hennepin Healthcare Research Institute	Completed	No outcome recorded
Phase 4	NCT01792037 Comparator	Dec 2012 → Mar 2013	adrenocortical insufficiency	Istanbul University	Completed	No outcome recorded
Phase 4	NCT01495949 Comparator	Dec 2011 → Dec 2013	coronary artery disorder, heart valve disorder	Mahidol University	Completed	No outcome recorded
Phase 4	NCT01386229 Comparator	Mar → Dec 2011	—	Baskent University	Unknown	No outcome recorded
Phase 4	NCT01474252 Background	Jul 2008 → Dec 2012	—	Siriraj Hospital	Completed	No outcome recorded
Phase 4	NCT00440102 Comparator	Apr 2007 → Mar 2008	—	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 4	NCT00596050 Comparator	Aug 2006 → Jun 2008	—	Drexel University College of Medicine	Completed	No outcome recorded
—	NCT07062601 Background	Jul → Nov 2025 overdue	tonsillitis	Anqing Municipal Hospital	Not yet recruiting	No outcome recorded
—	NCT05748665 Comparator	Aug 2023 → Jan 2024	—	Xijing Hospital	Completed	No outcome recorded
—	NCT05103696 Comparator	Oct 2021 → Dec 2022	—	Peking University People's Hospital	Completed	No outcome recorded
—	NCT04857450 Comparator	Nov 2020 → Nov 2021	anemia, cardiomyopathy, pulmonary hypertension	King Saud University	Unknown	No outcome recorded
—	NCT04120870 Comparator	Oct 2019 → Nov 2021	—	Ajou University School of Medicine	Terminated	No outcome recorded
—	NCT03852797 Comparator	Mar 2019 → Jan 2022	—	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Completed	No outcome recorded
—	NCT03855267 Comparator	Jan → Oct 2019	—	Guolin Wang	Unknown	No outcome recorded
—	NCT03129009 Comparator	Apr 2017 → Jun 2018	intracerebral hemorrhage	Xuzhou Medical University	Unknown	No outcome recorded
—	NCT02453373 Background	Jan 2017 → Jun 2023	brain ischemia, stroke disorder	Life Recovery Systems	Terminated	No outcome recorded
—	NCT02066077 Background	Jan 2013 → Dec 2017	major depressive disorder	Shanghai Mental Health Center	Completed	No outcome recorded
—	NCT01566838 Comparator	Oct 2012 → Dec 2015	—	Inova Health Care Services	Completed	No outcome recorded
—	NCT02667353 Background	Jun 2011 → Jun 2014	depressive disorder	Universitaire Ziekenhuizen KU Leuven	Completed	No outcome recorded
—	NCT00792779 Background	Nov 2008 → May 2009	hemolytic anemia	Centro Medico Campinas	Unknown	No outcome recorded
—	NCT00462644 Comparator	Feb → Aug 2006	adrenocortical insufficiency	University of Tennessee	Completed	No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 80 sources stand behind the page.

Field	Value	Cited text
Known as	etomidate	“Etomidate is a derivative of imidazole, and it can increase the reversibility of GABAA receptor activity, inhibit synaptic transmission and impulse conduction, and exert a...” NCT07019246 ↗ 79 “Total intravenous anesthesia induced with sufentanil,etomidate,cisatracurium and midazolam and maintained with propofol,cisatracurium and remifentanil target controlled infusion” NCT03129009 ↗ “general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg” NCT02154074 ↗ “The patients in the Sevoflurane Group (SG) will be induced with remifentanil TCI at target dose of 8.0 ηg.ml-1 and etomidate 0.5 mg.kg-1 in bolus.” NCT00792779 ↗ “Etomidate is a carboxylated imidazole-derived hypnotic, and it is the most cardiovascularly stable intravenous induction drug” NCT03240055 ↗ “Intravenous injection midazolam 0.05 mg/Kg,fentanyl 4μg/Kg,etomidate 0.2 mg/Kg,cisatracurium 0.15 mg/Kg in proper order.” NCT02289391 ↗ “Induction use Sufentanil 0.5\~1ug/kg, Vecuronium for Injection 0.15mg/kg and Etomidate 0.2\~0.6mg/kg” NCT02727712 ↗ “induction of anesthesia may be achieved with propofol and/or etomidate” NCT03263117 ↗ “induced with propofol (1-2mg/kg) or etomidate, fentanyl” NCT01566838 ↗ “Etomidate 1-2mg/kg” NCT01474252 ↗ “etomidate” NCT05358535 ↗ Show 69 more sources
Known as	Amidate	ChEMBL registry synonym — accepted as the source's own label CHEMBL681 ↗
Known as	Etomidato	ChEMBL registry synonym — accepted as the source's own label CHEMBL681 ↗
Known as	Hypnomidate	ChEMBL registry synonym — accepted as the source's own label CHEMBL681 ↗
Known as	NSC-759160	ChEMBL registry synonym — accepted as the source's own label CHEMBL681 ↗
Modality	Small molecule	“Etomidate is an imidazole derivative” NCT05277896 ↗
Route	Intravenous	“etomidate 0.3 mg/kg IV plus succinylcholine 1 mg/kg IV” NCT00462644 ↗