drugset / Trial / NCT02727712
Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study intends to compare the combination of general anesthesia (GA) and single-shot bilateral thoracic paravertebral block (TPVB) by ropivacaine in the patients undergoing off-pump coronary artery bypass surgery ( OPCAB) with traditional general anesthesia (GA) perioperative management of patients, committed to reducing patient's physical and psychological stress by surgical trauma, achieve the purpose of fast recovery, in order to establish an more effective perioperative management during off-pump coronary artery bypass surgery, improve patients' satisfaction and to accelerate postoperative rehabilitation safely.
Timeline
- Start
- 2016-04
- Primary completion
- 2016-09
- Completion
- 2016-12
Publications
- Background Olivier JF, Bracco D, Nguyen P, Le N, Noiseux N, Hemmerling T; Perioperative Cardiac Surgery Research Group (PeriCARG). A novel approach for pain management in cardiac surgery via median sternotomy: bilateral single-shot paravertebral blocks. Heart Surg Forum. 2007;10(5):E357-62. doi: 10.1532/HSF98.20071082.
- Results Ganapathy S, Murkin JM, Boyd DW, Dobkowski W, Morgan J. Continuous percutaneous paravertebral block for minimally invasive cardiac surgery. J Cardiothorac Vasc Anesth. 1999 Oct;13(5):594-6. doi: 10.1016/s1053-0770(99)90015-0. No abstract available.
- Results Mehta Y, Arora D, Sharma KK, Mishra Y, Wasir H, Trehan N. Comparison of continuous thoracic epidural and paravertebral block for postoperative analgesia after robotic-assisted coronary artery bypass surgery. Ann Card Anaesth. 2008 Jul-Dec;11(2):91-6. doi: 10.4103/0971-9784.41576.
- Results Dhole S, Mehta Y, Saxena H, Juneja R, Trehan N. Comparison of continuous thoracic epidural and paravertebral blocks for postoperative analgesia after minimally invasive direct coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2001 Jun;15(3):288-92. doi: 10.1053/jcan.2001.23271.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | — |
| Background | Dexmedetomidine | Other / unclassified | 1 ug/kg | — |
| Background | Etomidate | Small molecule | 0.2 mg/kg | — |
| Background | Etomidate | Small molecule | 0.6 mg/kg | — |
| Background | Hydromorphone | Other / unclassified | 0.15 mg/kg | Intravenous |
| Background | Sevoflurane | Other / unclassified | — | — |
| Background | Sufentanil | Other / unclassified | 0.01 ug/kg | — |
| Background | Sufentanil | Other / unclassified | 0.04 ug/kg | — |
| Background | Vecuronium | Small molecule | 0.06 mg/kg | — |
| Background | Vecuronium | Small molecule | 0.12 mg/kg | — |