drugset / Trial / NCT02518789
Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus
RandomizedParallel-groupDouble-blindTreatment
Summary
By observing the difference of plasma homovanillic acid concentrations and brain electrical consciousness monitoring Narcotrend index, study the possible mechanism of influencing Etomidate induced myoclonus with Dexmedetomidine pretreatment during general anesthesia induction period.
Timeline
- Start
- 2015-09
- Primary completion
- 2016-08
- Completion
- 2016-09
Publications
- Background Schwarzkopf KR, Hueter L, Simon M, Fritz HG. Midazolam pretreatment reduces etomidate-induced myoclonic movements. Anaesth Intensive Care. 2003 Feb;31(1):18-20. doi: 10.1177/0310057X0303100103.
- Background Stockham RJ, Stanley TH, Pace NL, Gillmor S, Groen F, Hilkens P. Fentanyl pretreatment modifies anaesthetic induction with etomidate. Anaesth Intensive Care. 1988 May;16(2):171-6. doi: 10.1177/0310057X8801600207.
- Background Doenicke AW, Roizen MF, Kugler J, Kroll H, Foss J, Ostwald P. Reducing myoclonus after etomidate. Anesthesiology. 1999 Jan;90(1):113-9. doi: 10.1097/00000542-199901000-00017.
- Background Paris A, Philipp M, Tonner PH, Steinfath M, Lohse M, Scholz J, Hein L. Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 2003 Oct;99(4):889-95. doi: 10.1097/00000542-200310000-00022.
- Background Maze M, Virtanen R, Daunt D, Banks SJ, Stover EP, Feldman D. Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies. Anesth Analg. 1991 Aug;73(2):204-8. doi: 10.1213/00000539-199108000-00015.
- Background Venn RM, Bryant A, Hall GM, Grounds RM. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. Br J Anaesth. 2001 May;86(5):650-6. doi: 10.1093/bja/86.5.650.
- Background Mizrak A, Koruk S, Bilgi M, Kocamer B, Erkutlu I, Ganidagli S, Oner U. Pretreatment with dexmedetomidine or thiopental decreases myoclonus after etomidate: a randomized, double-blind controlled trial. J Surg Res. 2010 Mar;159(1):e11-6. doi: 10.1016/j.jss.2009.07.031. Epub 2009 Aug 19.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | Intravenous |
| Subject | Dexmedetomidine | Other / unclassified | 1 ug/kg | Intravenous |
| Background | Cisatracurium | Small molecule | 0.05 mg/kg | Intravenous |
| Background | Cisatracurium | Small molecule | 0.1 mg/kg | Intravenous |
| Background | Etomidate | Small molecule | 0.3 mg/kg | Intravenous |
| Background | Fentanyl | Other / unclassified | 5 g/kg | Intravenous |
| Background | Fentanyl | Other / unclassified | 8 g/kg | Intravenous |
| Background | Midazolam | Small molecule | 0.03 mg/kg | Intravenous |
| Background | Midazolam | Small molecule | 0.05 mg/kg | Intravenous |
| Background | Propofol | Small molecule | 4 mg/kg | Intravenous |
| Background | Propofol | Small molecule | 6 mg/kg | Intravenous |
| Background | Remifentanil | Small molecule | 0.1 ug/kg | Intravenous |
| Background | Remifentanil | Small molecule | 0.3 ug/kg | Intravenous |
| Background | Rocuronium | Other / unclassified | 0.6 mg/kg | Intravenous |
Indications
No indication recorded.