Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block

Phase 2/3 Completed 24 enrolled Assiut University

RandomizedParallel-groupDouble-blindTreatment

Summary

TAP-block has been shown to be a safe and effective postoperative analgesia method in a variety of general. Dexmedetomidine is a selective α2 agonist with 8 times more affinity for α2 adrenergic receptors compared to clonidine and possesses all the properties of α2 agonist without respiratory depression. Dexmedetomidine has been focus of interest for its broad spectrum (sedative, analgesic and anesthetic sparing) properties, making it a useful and safe adjunct in many clinical applications.

Timeline

Start: 2017-11-11
Primary completion: 2018-12-01
Completion: 2019-09-01

Publications

El Sherif FA, Abdel-Ghaffar H, Othman A, Mohamed S, Omran M, Shouman S, Hassan N, Allam A, Hassan S. Pharmacokinetics and Pharmacodynamics of Dexmedetomidine Administered as an Adjunct to Bupivacaine for Transversus Abdominis Plane Block in Patients Undergoing Lower Abdominal Cancer Surgery. J Pain Res. 2022 Jan 4;15:1-12. doi: 10.2147/JPR.S335806. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dexmedetomidine	Other / unclassified	1 ug/kg	Other
Comparator	Bupivacaine	Other / unclassified	0.5 %	Other
Comparator	Bupivacaine	Other / unclassified	20 ml	Other

Indications

No indication recorded.