Intrathecal Morphine and Fentanyl for Knee Arthroplasty

Unknown 111 enrolled Keimyung University Dongsan Medical Center

RandomizedParallel-groupTriple-blindPrevention

Summary

This study is planned to investigate the efficacy of combined infusion of intrathecal morphine and fentanyl in patients undergoing total knee arthroplasty.

Timeline

Start: 2018-01-01
Primary completion: 2019-01-01
Completion: 2019-02-01

Outcome

Met primary endpoint

paper At 6 h, resting pain scores were significantly lower in the MF group than in the F and M groups (1.5 ± 0.9 vs. 4.2 ± 2.7 and 2.7 ± 2.0; P < 0.001). PMID 42185960 ↗

Publications

Park SK, Lee J, Gim DY, Park J, Kim HC. Combined intrathecal fentanyl and morphine for postoperative analgesia after total knee arthroplasty: a randomised controlled trial. BMC Anesthesiol. 2026 May 25;26(1):435. doi: 10.1186/s12871-026-03940-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	25 ug	Intrathecal
Subject	Morphine	Other / unclassified	100 ug	Intrathecal