drugset / Trial / NCT03456661

Comparison Between Levobupivacaine and Levobupivacaine With Dexmedetomidine in Ultrasound Guided Pectoral Nerve Block

NCT03456661

Phase 4 Terminated 40 enrolled University Hospital, Antwerp
RandomizedParallel-groupQuadruple-blindSupportive care

Summary

A double blind prospective randomized controlled trial in which the effect of single shot levobupivacaine 0,25% will be compared with the effect of levobupivacaine 0.25% in association with dexmedetomidine when performing an ultrasound guided modified pectoral nerve block , in patients undergoing a mastectomy with axillar procedure. The difference in effect will be evaluated by monitoring the postoperative morphine consumption in both groups . The hypothesis is that there is a significant decrease in morphine consumption during the first 24h postoperatively due to association of dexmedetomidine to the local anesthetic compared to the local anesthetic alone when performing a ultrasound guided modified pectoral nerve block. The morphine consumption will be the primary outcome parameter.

Timeline

Start
2014-05-19
Primary completion
2018-01-12
Completion
2018-01-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexmedetomidine Other / unclassified 50 ug Other
Comparator Levobupivacaine Other / unclassified 0.25 % Other
Comparator Levobupivacaine Other / unclassified 29.5 ml Other

Indications