Unique Effects of Perimenstrual Estradiol or Progesterone Supplementation on Perimenstrual Suicidality

Summary

This within-person, crossover, 3-condition, placebo-controlled study compares the impact of three perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide attempt. The three conditions are (1) perimenstrual withdrawal from estradiol only (during progesterone stabilization), (2) perimenstrual withdrawal from progesterone only (during estradiol stabilization), and (3) perimenstrual withdrawal from both estradiol and progesterone during placebo.

Timeline

Start

2018-07-27

Primary completion

2021-05-09

Completion

2021-05-09

Publications

• Law KC, O'Connell KL, Barone JC, Eisenlohr-Moul TA. Examining Suicidal Ideation and Capability Across the Menstrual Cycle. Suicide Life Threat Behav. 2026 Apr;56(2):e70084. doi: 10.1111/sltb.70084.

Drugs

Indications

No indication recorded.