drugset / Trial / NCT03613792
Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy
RandomizedParallel-groupDouble-blindSupportive care
Summary
This randomized controlled pilot clinical trial will enroll patients undergoing dynamic flexible bronchoscopy will be randomized to receive one of the two anesthetic combinations described above. The study will determine if there is a difference when considering patient and physician and satisfaction when performing DFB. Also, safety and efficacy of the two pharmacological combinations (fentanyl + midazolam and remifentanil + ketamine) used will be evaluated.
Timeline
- Start
- 2023-09
- Primary completion
- 2023-12
- Completion
- 2023-12
Outcome
Outcome not reported
Stopped: “Change in procedure means limited value for study question”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Fentanyl | Other / unclassified | 0.5 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 2 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 25 ug | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 50 ug | Intravenous |
| Comparator | Ketamine | Small molecule | 10 mg | — |
| Comparator | Ketamine | Small molecule | 40 mg | — |
| Comparator | Midazolam | Small molecule | 1 mg | Intravenous |
| Comparator | Midazolam | Small molecule | 5 mg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.1 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.15 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.2 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.4 ug/kg | Intravenous |
Indications
No indication recorded.