drugset / Trial / NCT03735628
An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors
Non-randomizedSequentialOpen-labelTreatment
Summary
The purpose of the dose escalation part of this study is to determine the feasibility of using the combination of copanlisib and nivolumab in subjects with advanced solid tumors, and to determine the maximum tolerated dose of copanlisib in combination with nivolumab. The maximum tolerated dose will then be used in Phase 2 (dose expansion) of the study.
Timeline
- Start
- 2018-10-17
- Primary completion
- 2022-10-13
- Completion
- 2022-10-13
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Copanlisib | Small molecule | 45 mg | — |
| Subject | Copanlisib | Small molecule | 60 mg | — |
| Subject | Nivolumab | Monoclonal antibody | 240 mg | — |