Impact of Acetaminophen on Postoperative Delirium Elderly Patients After Non-cardiac Surgery

Summary

To investigate the impact of acetaminophen analgesia on the frequency of postoperative delirium and 28 days mortality in elderly patients after noncardiac surgery.

Timeline

Start

2019-02-15

Primary completion

2020-02-01

Completion

2020-11-01

Outcome

Missed primary endpoint

paper Oral acetaminophen did not lead to a reduced POD risk (risk ratio = 0.6; 95% CI: 0.3 to 1.4; P = 0.262). PMID 42028138 ↗

Publications

• Zhang L, Peng M, Zhang H, Xiang C, Ai Y, Kong Y, Xiang M, Qian Z, Meng L. Oral acetaminophen and postoperative delirium in noncardiac surgical older patients requiring intensive care unit admission: A pragmatic randomized controlled trial. J Intensive Med. 2025 Dec 26;6(2):141-149. doi: 10.1016/j.jointm.2025.10.005. eCollection 2026 Apr.

Drugs

Indications