Blocking Mifepristone Action With Progesterone

Summary

Double-blind randomized trial to evaluate the potential impact of progesterone treatment on early pregnancies exposed to mifepristone.

Timeline

Start

2019-02-11

Primary completion

2019-07-29

Completion

2019-08-15

Outcome

Results reported · no primary-endpoint met/missed verdict (typical of a dose-finding / safety study)

Stopped: “Safety”

paper We could not estimate the efficacy of progesterone for mifepristone antagonization due to safety concerns PMID 31809439 ↗

Publications

• Creinin MD, Hou MY, Dalton L, Steward R, Chen MJ. Mifepristone Antagonization With Progesterone to Prevent Medical Abortion: A Randomized Controlled Trial. Obstet Gynecol. 2020 Jan;135(1):158-165. doi: 10.1097/AOG.0000000000003620.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Progesterone	Other / unclassified	400 mg	Oral
Background	Mifepristone	Small molecule	200 mg	Oral

Indications

No indication recorded.