Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis

Summary

Cure rate for L braziliensis bolivian CL has been 70%-80% for standard systemic and local monotherapies. It would benefit patients if cure rates could be consistently \>90%, so testing a combination of two treatments is proposed. The most attractive systemic therapy is the only oral agent, miltefosine during 28 days, and the most attractive local therapy is application of Paromomycin cream for 28 days.

Timeline

Start

2019-02-01

Primary completion

2020-12-01

Completion

2020-12-31

Drugs

Indications