drugset / Trial / NCT03844776

Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery

NCT03844776

Unknown 135 enrolled Taibah University
RandomizedSingle-groupDouble-blindTreatment

Summary

There was no evidence to judge the effects of preventative antibiotics for extractions of severely decayed teeth, teeth in diseased gums, or extractions in patients who are sick or have low immunity to infection. Undertaking research in these groups of people may not be possible or ethical. However, it is likely that in situations where patients are at a higher risk of infection that preventative antibiotics may be beneficial, because infections in this group are likely to be more frequent and more difficult to treat To the best of knowledge, no adult study has compared the effects of single dose of Co-Amoxiclave and full oral course before or after dentoalveolar surgery. The current study has formally considered this comparison as a potential valuable trail for reducing the postoperative complications in adult patients who have had surgical removal of teeth under LA.

Timeline

Start
2019-10-02
Primary completion
2020-12-02
Completion
2021-01-20

Drugs

EvaluationDrugModalityDoseRoute
Comparator Amoxicillin Other / unclassified 500 mg Oral
Comparator Amoxicillin Other / unclassified 625 mg Oral
Comparator Metronidazole Small molecule 500 mg Oral
Comparator Acetaminophen Small molecule 1 g Oral
Comparator Chlorhexidine Small molecule 0.2 % Other

Indications