drugset / Trial / NCT03848754

Pracinostat and Gemtuzumab Ozogamicin (PraGO) in Patients With Relapsed/Refractory Acute Myeloid Leukemia

NCT03848754

Phase 1 Completed 14 enrolled Medical College of Wisconsin
Non-randomizedSequentialOpen-labelTreatment

Summary

This is a prospective, single-center phase 1 clinical study aimed at determining the maximum-tolerated dose and safety of the combination of gemtuzumab ozogamicin (GO) and pracinostat (P) in patients with relapsed/refractory acute myeloid leukemia.

Timeline

Start
2019-05-24
Primary completion
2021-05-05
Completion
2021-05-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Gemtuzumab Ozogamicin Monoclonal antibody 2 mg/m2 Intravenous
Subject Gemtuzumab Ozogamicin Monoclonal antibody 3 mg/m2 Intravenous
Subject Pracinostat Other / unclassified 45 mg Oral
Subject Pracinostat Other / unclassified 60 mg Oral