drugset / Trial / NCT04002011
DOAC Versus VKA After Cardiac Surgery
RandomizedParallel-groupOpen-labelTreatment
Summary
Postoperative management of oral anticoagulation is a frequent preoccupation in cardiac surgery, concerning about half of patients. Vitamin K antagonists are often recommended but their management is not easy due to the high dose-response patient variability. Pharmacologically more stable, direct oral anticoagulants have similar efficiency in preventing thromboembolic complications while they decrease the risk of bleeding in certain patient populations. The objective of study is to assess the safety and efficacy of direct oral anticoagulants in the postoperative period of cardiac surgical procedures.
Timeline
- Start
- 2022-03-09
- Primary completion
- 2023-01-01
- Completion
- 2023-03-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Apixaban | Small molecule | — | Oral |
| Comparator | Dabigatran | Unknown | — | Oral |
| Comparator | Edoxaban | Small molecule | — | Oral |
| Comparator | Rivaroxaban | Other / unclassified | — | Oral |
| Comparator | Warfarin | Small molecule | — | Oral |