Drugs / Rivaroxaban
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Rivaroxaban

Other / unclassified targets F10 via inhibition

Developed for
venous thromboembolism · atrial fibrillation · thrombotic disease · coronary artery disorder · peripheral arterial disease · acute coronary syndrome · ischemic stroke · stroke disorder
+76 more · pulmonary embolism · COVID-19 · ST-elevation myocardial infarction · cancer · antiphospholipid syndrome · cerebral sinovenous thrombosis · cirrhosis of liver · heart failure · intracerebral hemorrhage · myocardial infarction · neoplasm · portal vein thrombosis · cardiac valvular defect · rheumatic heart disease · thrombophlebitis · transient ischemic attack · aortic valve disorder · aortic valve stenosis · arterial occlusion · blood coagulation disease · coronary aneurysm · end stage renal failure · impaired renal function disease · intermediate coronary syndrome · intracranial arteriosclerosis · Kawasaki disease · May-Thurner syndrome · migraine disorder · mitral valve stenosis · plasma cell myeloma · sickle cell disease · vascular ectasia · acquired polycythemia vera · atherosclerosis · atrial flutter · Behcet disease · brain ischemia · cardiac rhythm disease · cardiovascular disorder · carotid stenosis · cerebral atherosclerosis · cerebral infarction · chronic kidney disease · chronic obstructive pulmonary disease · diabetes mellitus, noninsulin-dependent, 2 · esophageal varices with bleeding · essential thrombocythemia · heart valve disorder · heparin-induced thrombocytopenia · hyperheparinemia · hypertrophic cardiomyopathy · idiopathic membranous glomerulonephritis · intermittent vascular claudication · intracranial arterial disease · intracranial embolism · isolated mesenteric vein thrombosis · isolated splenic vein thrombosis · limb ischemia · malignant glioma · malignant urinary system neoplasm · mitral valve insufficiency · osteoporosis · postoperative ventricular dysfunction · primary myelofibrosis · severe acute respiratory syndrome · sickle cell-beta zero-thalassemia · systemic lupus erythematosus · bleeding disorder, vascular-type · calcinosis · coronary atherosclerosis · diabetes mellitus · infective endocarditis · post-thrombotic syndrome · staphylococcal toxemia · staphylococcus aureus infection · traumatic brain injury
Investigated by
Bayer · Janssen Research & Development, LLC · Janssen Scientific Affairs, LLC · Population Health Research Institute · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Assistance Publique - Hôpitaux de Paris
+296 more · Insel Gruppe AG, University Hospital Bern · Ottawa Hospital Research Institute · Second Affiliated Hospital, School of Medicine, Zhejiang University · National Heart, Lung, and Blood Institute (NHLBI) · Shanghai Zhongshan Hospital · Hamilton Health Sciences Corporation · Radboud University Medical Center · Science Valley Research Institute · Seoul National University Hospital · University Hospital of Saint-Etienne · Asan Medical Center · Canadian Institutes of Health Research (CIHR) · China National Center for Cardiovascular Diseases · Imperial College London · Ottawa Heart Institute Research Corporation · RenJi Hospital · Rigshospitalet, Denmark · The Ottawa Hospital · University Hospital, Angers · University Hospital, Brest · University of Florida · Xijing Hospital · Yonsei University · Aalborg University Hospital · Aarhus University Hospital · Anhui Provincial Hospital · Centre Hospitalier Universitaire Vaudois · Charite University, Berlin, Germany · Children's Hospital of Fudan University · Chinese Academy of Medical Sciences, Fuwai Hospital · GWT-TUD GmbH · Gødstrup Hospital · Heart and Stroke Foundation of Canada · Hospital Universitari Vall d'Hebron Research Institute · Huadong Hospital · Huashan Hospital · Instituto Nacional de Cardiologia Ignacio Chavez · Massachusetts General Hospital · McMaster University · Medical University of Graz · Medical University of South Carolina · Medtronic · Ministry of Health, France · Northwestern University · Odense University Hospital · Onze Lieve Vrouw Hospital · Oslo University Hospital · Queen Elizabeth II Health Sciences Centre · Rajaie Cardiovascular Medical and Research Center · Regeneron Pharmaceuticals · Shanghai 5th People's Hospital · Sir Run Run Shaw Hospital · The First Affiliated Hospital with Nanjing Medical University · University College, London · University of Alberta · University of Cape Town · University of Padova · University of Sao Paulo General Hospital · Vanderbilt University Medical Center · Yantai Yuhuangding Hospital · AHEPA University Hospital · AIO-Studien-gGmbH · AZ Sint-Jan AV · Aalborg University · Abbott · Abidi Pharmaceuticals · Academisch Ziekenhuis Groningen · Action Research Group · Addpharma Inc. · Affiliated Hospital of Jiaxing University · Ahmed AbdelMoneim Hassan Ali · Ain Shams University · Air Force Military Medical University, China · Alexandria University · all 302 on the full record

Regulatory milestones approvals, filings & regulatory actions · 10 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (8) US (FDA) XARELTO 2012-11-02 – 2021-08-23 fda.gov
Approved US (FDA) XARELTO 2011-07-01 fda.gov
Approved EU (EMA) Xarelto 2008-09-30 europa.eu

Trials 281 · started per year

today
EU approved 2008
US approved 2011
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20032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT06961630 Oct 2025 → Mar 2027 expected myocardial infarction NYU Langone Health Recruiting No outcome recorded
Phase 0 NCT07011095 Sep 2025 → Feb 2027 expected atrial fibrillation Population Health Research Institute Not yet recruiting No outcome recorded
Phase 0 NCT05308030 Aug 2022 → May 2023 peripheral arterial disease Assiut University Unknown No outcome recorded
Phase 0 NCT04994223 Jul 2021 → Dec 2022 peripheral arterial disease Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi Unknown No outcome recorded
Phase 130 trials
Phase 1 NCT06913595 Mar 2024 → Oct 2025 overdue venous thromboembolism Cairo University Active not recruiting No outcome recorded
Phase 1 NCT06372483 Feb → Aug 2024 overdue blood coagulation disease VarmX B.V. Active not recruiting No outcome recorded
Phase 1 NCT05723510 Mar → Jul 2023 HK inno.N Corporation Completed No outcome recorded
Phase 1 NCT07077954 Jan → Jun 2023 venous thromboembolism Children Hospital and Institute of Child Health, Lahore Completed No outcome recorded
Phase 1 NCT04767776 Jan → Sep 2022 University Hospital of Saint-Etienne Completed No outcome recorded
Phase 1 NCT05128591 Nov → Dec 2021 thrombotic disease Addpharma Inc. Completed No outcome recorded
Phase 1 NCT04874428 May 2021 → Jun 2026 overdue cirrhosis of liver Insel Gruppe AG, University Hospital Bern Recruiting No outcome recorded
Phase 1 NCT05418803 Jan → Feb 2020 Yuhan Corporation Completed No outcome recorded
Phase 1 NCT04180436 Jan 2020 → Jun 2022 morbid obesity University Hospital, Brest Completed No outcome recorded
Phase 1 NCT03864406 Jun 2019 → Dec 2022 National Institutes of Health Clinical Center (CC) Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT03747081 Sep 2018 → Jan 2020 cerebral sinovenous thrombosis Isfahan University of Medical Sciences Unknown No outcome recorded
Phase 1/2 NCT04397289 Feb 2018 → Mar 2021 cirrhosis of liver, hemorrhagic disease, portal hypertension, thrombotic disease First Affiliated Hospital Xi'an Jiaotong University Completed No outcome recorded
Phase 1/2 NCT03282643 Feb 2016 → Jun 2018 neoplasm Capital Medical University Completed No outcome recorded
Phase 1/2 NCT02564718 Nov 2015 → Dec 2017 thrombotic disease Bayer Completed No outcome recorded
Phase 234 trials
Phase 2 NCT07246005 Dec 2026 → Dec 2027 expected thrombotic disease Queen Mary University of London Not yet recruiting No outcome recorded
Phase 2 NCT05775965 May 2024 → Mar 2025 overdue osteoporosis University of Calgary Recruiting No outcome recorded
Phase 2 NCT05546320 Oct 2022 → Mar 2025 migraine disorder, patent foramen ovale Chinese Academy of Medical Sciences, Fuwai Hospital Completed No outcome recorded
Phase 2 NCT05006287 Oct 2022 → May 2024 atrial fibrillation St. Paul's Hospital, Canada Unknown No outcome recorded
Phase 2 NCT05033964 Dec 2021 → Dec 2022 overdue coronary artery disorder Elixir Medical Corporation Active not recruiting No outcome recorded
Phase 2 NCT05233124 Sep 2021 → Jun 2023 acute coronary syndrome, vascular ectasia Instituto Nacional de Cardiologia Ignacio Chavez Unknown No outcome recorded
Phase 2 NCT03684564 Jul 2021 → Jul 2025 antiphospholipid syndrome, brain ischemia, ischemic stroke, systemic lupus erythematosus University College, London Completed No outcome recorded
Phase 2 NCT04416048 Nov 2020 → Jul 2021 COVID-19 Charite University, Berlin, Germany Terminated No outcome recorded
Phase 2 NCT04504032 Sep 2020 → Mar 2021 COVID-19 Gates Medical Research Institute Terminated No outcome recorded
Phase 2 NCT03178864 Mar 2019 → Oct 2022 cerebral sinovenous thrombosis University of British Columbia Completed No outcome recorded
Phase 2/38 trials
Phase 2/3 NCT06965998 Aug 2025 → Aug 2026 overdue thrombophlebitis, thrombotic disease Ottawa Hospital Research Institute Recruiting No outcome recorded
Phase 2/3 NCT05920343 Nov 2024 → Oct 2026 expected malignant urinary system neoplasm, venous thromboembolism Ottawa Hospital Research Institute Recruiting No outcome recorded
Phase 2/3 NCT05700266 Dec 2023 → Dec 2024 intracranial arteriosclerosis, ischemic stroke The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
Phase 2/3 NCT04273516 Aug 2020 → Apr 2023 ischemic stroke Mazandaran University of Medical Sciences Completed No outcome recorded
Phase 2/3 NCT04351724 Apr 2020 → Dec 2021 COVID-19 Medical University of Vienna Unknown No outcome recorded
Phase 2/3 NCT03428373 Jan 2019 → Dec 2023 plasma cell myeloma London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Unknown No outcome recorded
Phase 2/3 NCT03273322 Sep 2017 → Nov 2018 atrial fibrillation, hemorrhagic disease Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 2/3 NCT01923818 Sep 2013 → Sep 2015 transient ischemic attack Xijing Hospital Unknown No outcome recorded
Phase 397 trials
Phase 3 NCT07318610 Jul 2026 → Aug 2029 expected peripheral arterial disease Regeneron Pharmaceuticals Recruiting No outcome recorded
Phase 3 NCT07468448 May 2026 → Dec 2029 expected cerebral atherosclerosis, ischemic stroke Population Health Research Institute Not yet recruiting No outcome recorded
Phase 3 NCT07202897 Jan 2026 → Jan 2032 expected hypertrophic cardiomyopathy Rennes University Hospital Recruiting No outcome recorded
Phase 3 NCT07456085 Nov 2025 → Apr 2027 expected heart valve disorder Rawalpindi Institute of Cardiology Enrolling by invitation No outcome recorded
Phase 3 NCT06580223 Sep 2025 → Sep 2027 expected plasma cell myeloma, venous thromboembolism Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Not yet recruiting No outcome recorded
Phase 3 NCT06780462 Jun 2025 → Dec 2027 expected Behcet disease Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT05410275 Jan 2025 → Jan 2027 expected chronic kidney disease University Hospital, Tours Recruiting No outcome recorded
Phase 3 NCT06611319 Nov 2024 → Mar 2027 expected osteoarthritis, hip, venous thromboembolism Prof. Stavros Konstantinides, MD Recruiting No outcome recorded
Phase 3 NCT06195540 Jul 2024 → Nov 2028 expected pulmonary embolism, venous thromboembolism University Hospital, Angers Recruiting No outcome recorded
Phase 3 NCT05387954 Jul 2023 → Jul 2031 expected ischemic stroke, patent foramen ovale Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 472 trials
Phase 4 NCT07609654 Jun 2026 → Jun 2029 expected atrial fibrillation, intracerebral hemorrhage, ischemic stroke Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 4 NCT07511257 Feb 2026 → Jun 2029 expected ST-elevation myocardial infarction, acute coronary syndrome, vascular ectasia Instituto Nacional de Cardiologia Ignacio Chavez Recruiting No outcome recorded
Phase 4 NCT07195812 Oct 2025 → May 2028 expected ST-elevation myocardial infarction Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 4 NCT06901466 Jun 2025 → Oct 2027 expected mitral valve insufficiency Chinese Academy of Medical Sciences, Fuwai Hospital Recruiting No outcome recorded
Phase 4 NCT05643651 Jun 2025 → Jun 2027 expected Kawasaki disease, coronary aneurysm Children's Hospital of Fudan University Recruiting No outcome recorded
Phase 4 NCT06812455 Mar 2025 → Mar 2028 expected arterial occlusion AHEPA University Hospital Recruiting No outcome recorded
Phase 4 NCT06108414 Sep 2024 → Dec 2026 expected atrial fibrillation, stroke disorder China National Center for Cardiovascular Diseases Recruiting No outcome recorded
Phase 4 NCT07618988 Aug 2024 → Dec 2025 venous thromboembolism Ain Shams University Completed No outcome recorded
Phase 4 NCT06476301 Aug 2024 → Feb 2026 overdue RenJi Hospital Not yet recruiting No outcome recorded
Phase 4 NCT06401616 May 2024 → Mar 2028 expected atrial fibrillation Odense University Hospital Recruiting No outcome recorded
Phase not applicable31 trials
NCT07583784 Jul 2026 → Dec 2031 expected ST-elevation myocardial infarction, atrial fibrillation Chonnam National University Hospital Not yet recruiting No outcome recorded
NCT07602062 Jun 2026 → Dec 2027 expected esophageal varices with bleeding, portal vein thrombosis Shanghai Zhongshan Hospital Not yet recruiting No outcome recorded
NCT07613840 Apr 2025 → Apr 2027 expected peripheral arterial disease, thrombotic disease Massachusetts General Hospital Recruiting No outcome recorded
NCT07270263 Nov 2024 → Apr 2026 overdue leukemia, lymphoma, pulmonary embolism, venous thromboembolism Medical University of Gdansk Recruiting No outcome recorded
NCT06689241 Oct 2024 → Dec 2025 overdue morbid obesity Alexandria University Recruiting No outcome recorded
NCT06216769 Feb 2024 → Dec 2030 expected atrial fibrillation Seoul National University Hospital Recruiting No outcome recorded
NCT07523347 Dec 2023 → Dec 2025 cerebral sinovenous thrombosis Muhammad Aamir Latif Completed No outcome recorded
NCT06196918 Nov 2023 → Aug 2024 malignant glioma Nanfang Hospital, Southern Medical University Unknown No outcome recorded
NCT06057467 Sep 2023 → Oct 2025 atrial fibrillation, ischemic stroke Second Affiliated Hospital, School of Medicine, Zhejiang University Unknown No outcome recorded
NCT05960721 Jul 2023 → Jul 2025 overdue atrial fibrillation Xijing Hospital Recruiting No outcome recorded
Phase not stated1 trial
NCT02894307 cardiac valvular defect Hospital Ana Nery No longer available No outcome recorded
Also used as a comparator or background therapy in 110 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT06615596 Comparator Aug 2025 → Jan 2029 expected atrial fibrillation China National Center for Cardiovascular Diseases Recruiting No outcome recorded
Phase 0 NCT07032025 Comparator Jul 2025 → Jul 2027 expected pulmonary embolism RenJi Hospital Not yet recruiting No outcome recorded
Phase 0 NCT06145269 Comparator Dec 2023 → Apr 2025 venous thromboembolism Assiut University Unknown No outcome recorded
Phase 0 NCT02331095 Background Jan 2015 → Oct 2017 venous thromboembolism Ohio State University Terminated No outcome recorded
Phase 18 trials
Phase 1 NCT07312851 Background Jan → Jun 2026 AstraZeneca Completed No outcome recorded
Phase 1 NCT06831474 Comparator Jul 2025 → Apr 2026 overdue puerperal disorder, venous thromboembolism Thomas Jefferson University Recruiting No outcome recorded
Phase 1 NCT06444178 Comparator Sep 2024 → Apr 2025 Regeneron Pharmaceuticals Completed No outcome recorded
Phase 1 NCT06517563 Background Aug → Dec 2024 blood coagulation disease VarmX B.V. Completed No outcome recorded
Phase 1 NCT05491460 Comparator Jul 2022 → Dec 2023 Doasense GmbH Unknown No outcome recorded
Phase 211 trials
Phase 2 NCT06220123 Comparator Feb → Dec 2024 Beijing Suncadia Pharmaceuticals Co., Ltd Completed No outcome recorded
Phase 2 NCT05498428 Background Nov 2022 → Aug 2027 expected non-small cell lung carcinoma Janssen Research & Development, LLC Recruiting No outcome recorded
Phase 2 NCT04002011 Comparator Mar 2022 → Jan 2023 bleeding disorder, vascular-type Laval University Withdrawn No outcome recorded
Phase 2 NCT05088928 Comparator Mar → May 2022 COVID-19 Scotmann Pharmaceuticals Unknown No outcome recorded
Phase 2 NCT04755283 Comparator Feb 2021 → Feb 2024 overdue atrial fibrillation, stroke disorder Anthos Therapeutics, Inc. Active not recruiting No outcome recorded
Phase 2/35 trials
Phase 2/3 NCT04838808 Comparator Apr 2021 → May 2022 myocardial infarction University of Alberta Completed No outcome recorded
Phase 2/3 NCT05515120 Comparator Jan 2021 → Jan 2022 bleeding disorder, vascular-type, pulmonary embolism, venous thromboembolism Mexican Social Security Institute Completed No outcome recorded
Phase 2/3 NCT03566303 Comparator Jul 2018 → Apr 2020 blood coagulation disease, heart valve disorder, stroke disorder Hospital Geral Roberto Santos Terminated No outcome recorded
Phase 2/3 NCT02829957 Comparator Sep 2016 → Feb 2020 menstrual disorder, venous thromboembolism Indiana University Completed No outcome recorded
Phase 2/3 NCT01627665 Comparator Oct 2011 → Jun 2014 Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 314 trials
Phase 3 NCT07228663 Comparator Dec 2025 → Jul 2027 expected venous thromboembolism McMaster University Not yet recruiting No outcome recorded
Phase 3 NCT06925698 Comparator Apr 2025 → Apr 2027 expected Behcet disease, post-thrombotic syndrome, venous thromboembolism Marmara University Not yet recruiting No outcome recorded
Phase 3 NCT06322953 Comparator Mar 2025 → Dec 2027 expected traumatic brain injury Walton Centre NHS Foundation Trust Recruiting No outcome recorded
Phase 3 NCT06370273 Comparator Nov 2024 → Aug 2028 expected thrombotic disease Queen Mary University of London Recruiting No outcome recorded
Phase 3 NCT06551402 Comparator Aug 2024 → Oct 2026 expected cerebral sinovenous thrombosis Kafrelsheikh University Recruiting No outcome recorded
Phase 449 trials
Phase 4 NCT06396858 Comparator Jul 2026 → Aug 2027 expected ischemic stroke Brazilian Clinical Research Institute Not yet recruiting No outcome recorded
Phase 4 NCT06953726 Comparator Jun 2026 → Oct 2032 expected atrial fibrillation VA Office of Research and Development Recruiting No outcome recorded
Phase 4 NCT07352358 Background Jan 2026 → Jul 2028 expected cerebral sinovenous thrombosis Xuanwu Hospital, Beijing Recruiting No outcome recorded
Phase 4 NCT06650501 Comparator Jan 2026 → Jan 2030 expected infective endocarditis, staphylococcal toxemia, staphylococcus aureus infection McGill University Health Centre/Research Institute of the McGill University Health Centre Recruiting No outcome recorded
Phase 4 NCT06212674 Comparator Oct 2025 → Oct 2027 expected atrial fibrillation, ischemic stroke Medical University of Silesia Recruiting No outcome recorded
Phase not applicable19 trials
NCT07497893 Background Dec 2026 → Nov 2029 expected atrial fibrillation Ewha Womans University Mokdong Hospital Not yet recruiting No outcome recorded
NCT07616414 Comparator May → Dec 2026 expected atrial fibrillation, thrombotic disease Fu Wai Hospital, Beijing, China Not yet recruiting No outcome recorded
NCT05993897 Comparator Aug 2024 → Jun 2025 atrial fibrillation Aswan University Completed No outcome recorded
NCT04684212 Comparator Jun 2024 atrial fibrillation, stroke disorder Brian O'Neill MD Withdrawn No outcome recorded
NCT06021808 Comparator Apr 2024 → Apr 2028 expected atrial fibrillation China National Center for Cardiovascular Diseases Recruiting No outcome recorded

Evidence & citations 15 cited values

Every value below carries the sentence it was read from. 394 sources stand behind the page.

FieldValueCited text
Known as Rivaroxaban “AF patients with a CHA2DS2-VASc score >2 and no previous history of overt coronary disease, severe peripheral arterial disease (PAD) or major stroke will be registered and...” PMID 27558002 Aug 2016
388

“Patients will be chronically treated with NOAC including apixaban (2x5 mg or 2x2.5 mg depending on the dose reduction regimen) or dabigatran (2x150 mg or 2x110 mg depending on...” NCT06212674

“DOACs (eg Apixaban, dabigatran, edoxaban and rivaroxaban) are recommended by The National Institute for Health and Care Excellence (NICE) for those over 65 with AF and a...” NCT06322953

“NOAC includes dabigatran 150mg or 110mg twice daily, rivaroxaban 15mg daily with the reduced dose of 10mg daily, apixaban 5mg twice daily with the reduced dose of 2.5mg twice...” NCT01962545

“edoxaban 60 mg daily (dose reduction to 30 mg, if applicable), apixaban 5 mg twice daily (dose reduction to 2.5 mg, if applicable), dabigatran 110 mg twice daily, or...” NCT03968393

“Century Clot-guided rivaroxaban prophylactic therapy (2.5 mg twice daily, if the hypercoagulable state, defined as CR ≥24) in combination with standard DAPT could reduce LVT...” NCT06013020

“For patients with creatinine clearance ≥50 ml/min, oral rivaroxaban 20 mg daily was administered, whereas for patients with creatinine clearance between 30-49 ml/min, oral...” NCT06021808

“For those randomized to group B (NOAC group), patients will be treated using a registered NOAC (rivaroxaban, apixaban or dabigatran, but preferentionally apixaban) at the dose...” NCT02426944

“The dosage regimen of anticoagulant was hypodermic injection 0.4 ml low molecular weight heparin per day for 5 days and oral administration of 10 mg Rivaroxaban until one month...” NCT03804697

“Patients will be treated with warfarin with dose adjusted to goal International Normalized Ratio (INR) of 2-3 or rivaroxaban standard dose (15 mg twice daily for 3 weeks then...” NCT02331095

“Non-vitamin K antagonist oral anticoagulant therapy (e.g., apixaban, rivaroxaban, dabigatran, or edoxaban) administered according to approved labeling and guideline-recommended dosing.” NCT07497893

“The PK sub-study is being conducted to assess the blood pharmacokinetics of the three drugs (Sirolimus, Rivaroxaban, Argatroban) eluted from the DESyne BDS Plus after implantation.” NCT05033964

“Participants in the continuation arm will receive oral anticoagulant drugs such as dabigatran, rivaroxaban, apixaban, warfarin, etc. tailored to their specific risk profiles.” NCT06615596

“Patients allocated to the DAT group receive either apixaban 5 mg twice daily, edoxaban 60 mg once daily, or rivaroxaban 15 mg once daily with clopidogrel 75 mg once daily.” NCT07583784

“Apixaban 5mg twice daily (2.5mg twice daily if meets dose-reduction criteria) or rivaroxaban 20mg once daily (15mg once daily if meets dose-reduction criteria) for 2 years” NCT04437654

“Patients enrolled in the NOAC monotherapy arm would be administered with apixaban 5 mg twice daily or rivaroxaban 20 mg once daily for 2 years after randomization.” NCT04250116

“Antithrombotic agents include, but are not limited to: warfarin (titrated to international normalised ratio, INR), apixaban, rivaroxaban, aspirin, and clopidogrel.” NCT05622500

“This study aims to compare the effectiveness of rivaroxaban versus low molecular weight heparin in reducing the incidence of PMVT after bariatric surgery.” NCT06913595

“Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.” NCT06055920

“The patient will receive apixaban 2.5 mg twice daily or rivaroxaban 10 mg once daily during a mean follow-up period of 36 months (12 to 65 months)” NCT03285438

“Patients who are over 20 years old, have non-valvular atrial fibrillation, and are taking rivaroxaban, apixaban, or edoxaban (active ingredients)” NCT05801068

“Patients randomized to receive DOAC, at the choice of the investigator: Apixaban 2.5 mg both in day or Rivaroxaban 10 mg once daily.” NCT05198960

“DOA study medications (Apixaban, Rivaroxaban and Dabigatran) will be prescribed and supplied in the usual setting of patient care” NCT05825573

“Administration of approved DOACs (e.g., apixaban, rivaroxaban, edoxaban, or dabigatran) at standard stroke prevention dosages.” NCT07609654

“For rivaroxaban: 10mg once daily for patients with standard 15mg dose, 15mg once daily for patients with standard 20mg dose” NCT07616414

“Low-molecular-weight heparin bridging to warfarin 3 mg/day, rivaroxaban 10-20 mg/day or dabigatran 110-150 mg twice daily.” NCT07352358

“Apixaban or dabigatran or edoxaban or rivaroxaban at recommended dosing for stroke prevention in atrial fibrillation.” NCT02998905

“Patients will be treated with one of the available NOAC drugs; Apixaban, Dabigatran, Edoxaban or Rivaroxaban.” NCT03642509

“novel oral anticoagulant includes 'dabigatran,Pradaxa®', 'rivaroxaban,Xarelto®', and 'apixaban, Eliquis®'.” NCT02504177

Rivaroxaban 20mg orally once daily if CHA2DS2 VASc score 1 or more for males and 2 or more for females.” NCT05993897

Rivaroxaban 20mg once daily or 15mg once daily / Dabigatran 110mg twice daily or 150mg twice daily” NCT06058130

“Apixaban (5mg twice a day) OR Dabigatran (150 mg twice a day) OR Rivaroxaban (20 mg once a day)” NCT05387954

“using the direct oral anticoagulant Rivaroxaban (brand name: Xarelto) at the recommended dose.” NCT06611319

“Post-procedural oral anticoagulation is transitioned to rivaroxaban 20 mg once daily (QD).” NCT07032025

“choice of DOAC (apixaban, dabigatran, edoxaban or rivaroxaban) according to local practice” NCT04700826

“Dabigatran, Rivaroxaban, Apixaban or Edoxaban at standard dose as recommended by the MRP” NCT05472766

“any approved direct oral anticoagulant (apixaban, rivaroxaban, edoxaban or dabigatran)” NCT04045665

“direct oral anticoagulant treatment (apixaban, rivaroxaban, dabigatran, or edoxaban)” NCT01999179

“Anticoagulation agents includes rivaroxaban, dabigatran, apixaban, and edoxaban.” NCT06057467

“OAC drugs used: Dabigatran etexilate, Rivaroxaban, Warfarin, other approved VKA” NCT00559988

“Discontinuation of warfarin, dabigatran, rivaroxaban, apixaban or edoxaban” NCT06401616

“Anticoagulation with a NOAC (Apixaban, Dabigatran, Edoxaban, Rivaroxaban)” NCT05006287

“Pharmacogenomic Study on PKD/PKC of Dabigatran Etexilate and RivaroxabanNCT01627665

“Acetylsalicylic acid 100mg once daily plus rivaroxaban 2.5mg twice daily” NCT04619927

Rivaroxaban was given for minimum 4 weeks depending on D dimer levels” NCT04935515

“warfarin, dabigatran etexilate, rivaroxaban, apixaban, edoxaban usage” NCT01924065

“New oral anticoagulants (NOACs): dabigatran, rivaroxaban, apixaban” NCT02701062

“to receive either an 18-month or a 6-month rivaroxaban treatment” PMID 39556015 Nov 2024

Rivaroxaban 10 mg tablets will take 1 every 24 hours for 10 days” NCT04673214

“vitamin K antagonist, Apixiban 2.5mg bid or Rivaroxaban 15mg od” NCT02885545

“warfarin, dabigatran, rivaroxaban, apixaban, or edoxaban” NCT03062319

Rivaroxaban: 20 mg once a day or 15 mg once a day” NCT06862726

“dabigatran, apixaban, edoxaban, rivaroxabanNCT03759938

“group B : Rivaroxaban 10 mg plus placebo” NCT05705076

“Apixaban Dabigatran Edoxaban RivaroxabanNCT05292846

“Xarelto (Rivaroxaban, BAY59-7939)” NCT00973323

“Intervention Arm: RivaroxabanNCT07456085

Rivaroxaban (Xarelto)” NCT07011095

Rivaroxaban (Xarelto)” NCT03465735

Rivaroxaban (Xarelto)” NCT01706146

RIVAROXABAN 40 mg” NCT01627665

Rivaroxaban 2.5mg” NCT05418803

RivaroxabanNCT05300555

RivaroxabanNCT02666742

NCT05449327

NCT06901466

NCT02128841

NCT07468448

NCT04970381

NCT07270263

NCT02723981

NCT03566303

NCT03996772

NCT07523347

NCT05546957

NCT05546320

NCT06978439

NCT03792152

NCT07318610

NCT02935855

NCT04218656

NCT03605433

NCT02846532

NCT02123524

NCT03282643

NCT02555878

NCT04256525

NCT07511257

NCT06314763

NCT04767776

NCT06961630

NCT06396858

NCT02556203

NCT04258488

NCT03148457

NCT02506985

NCT03193502

NCT03083704

NCT03684564

NCT05735639

NCT06065592

NCT04967573

NCT02810704

NCT01094886

NCT03363035

NCT02085824

NCT00395772

NCT03568890

NCT03172910

NCT01853800

NCT01989845

NCT02024230

NCT07202897

NCT06517563

NCT01499953

NCT04263038

NCT02627053

NCT05515120

NCT05077683

NCT03764241

NCT03178864

NCT04757857

NCT00786422

NCT05705089

NCT04755283

NCT01629381

NCT04397289

NCT01464450

NCT03273322

NCT05033314

NCT04838808

NCT05047172

NCT02497716

NCT05180773

NCT06925698

NCT06449469

NCT05035277

NCT02072668

NCT05701917

NCT01379300

NCT02157272

NCT00809965

NCT05152420

NCT07246005

NCT03673605

NCT01400646

NCT06531122

NCT05718531

NCT06650501

NCT01986192

NCT02722447

NCT02704598

NCT05700266

NCT03428373

NCT07699796

NCT02401594

NCT02438098

NCT02168829

NCT01708850

NCT01747746

NCT02334254

NCT04169269

NCT05491460

NCT04853719

NCT04273516

NCT03969953

NCT05487950

NCT04351724

NCT03702582

NCT04990791

NCT02042534

NCT02303795

NCT03005444

NCT03055026

NCT05892042

NCT01877915

NCT07243080

NCT02260622

NCT05300555

NCT05303818

NCT02559856

NCT03201367

NCT03153150

NCT03129490

NCT06953726

NCT03328832

NCT01309438

NCT03331484

NCT05308030

NCT06019741

NCT06986369

NCT03463317

NCT02974920

NCT04284839

NCT03129555

NCT01839357

NCT03139487

NCT05088928

NCT06551402

NCT05638867

NCT03578146

NCT04727021

NCT01442792

NCT00973245

NCT00329628

NCT03277001

NCT06831474

NCT06444178

NCT01656330

NCT04874428

NCT04023630

NCT04135677

NCT04640181

NCT02379663

NCT04642430

NCT06187311

NCT02583191

NCT05775965

NCT06108414

NCT04805710

NCT01431456

NCT05116995

NCT05643651

NCT05009862

NCT02234843

NCT00396786

NCT03799822

NCT04994223

NCT05210725

NCT00332020

NCT02664155

NCT02666157

NCT05920343

NCT02116036

NCT04569279

NCT01210755

NCT06689241

NCT00494871

NCT01954238

NCT01478282

NCT01674647

NCT05744804

NCT02453802

NCT01729871

NCT01344954

NCT04720092

NCT06103266

NCT04180436

NCT02549963

NCT04394377

NCT01675076

NCT04333407

NCT06370273

NCT02271399

NCT04970576

NCT00839826

NCT04715295

NCT04059679

NCT03864406

NCT02066662

NCT02642419

NCT00403767

NCT06476301

NCT07312851

NCT00398905

NCT00362232

NCT04486859

NCT01776424

NCT02058199

NCT00361894

NCT01812200

NCT02561923

NCT06195540

NCT00562289

NCT01145859

NCT02331602

NCT02657512

NCT06780462

NCT00779064

NCT06196918

NCT00839163

NCT04006288

NCT04662684

NCT01205932

NCT02744092

NCT03718429

NCT02643212

NCT02970773

NCT03786757

NCT04416048

NCT07602062

NCT02833948

NCT00402597

NCT01923818

NCT05353140

NCT02289703

NCT02832947

NCT04508023

NCT02293395

NCT04075240

NCT02746185

NCT02926170

NCT05233124

NCT02313909

NCT04142125

NCT04324463

NCT00440193

NCT02376010

NCT06873321

NCT03490994

NCT02504216

NCT03413618

NCT05410275

NCT00571649

NCT06965998

NCT04999176

NCT00402467

NCT03926780

NCT01598168

NCT01206972

NCT04504032

NCT03181386

NCT06580223

NCT03506815

NCT03749057

NCT02832531

NCT03796377

NCT02054936

NCT07613840

NCT03926156

NCT04694248

NCT04309240

NCT06372483

NCT06145269

NCT04794569

NCT05797376

NCT02584660

NCT02894307

NCT02486445

NCT03310021

NCT04066764

NCT05128591

NCT05973188

NCT03630055

NCT07404436

NCT04002011

NCT02161965

NCT03196349

NCT04073316

NCT07228663

NCT06216769

NCT00439777

NCT01507051

NCT02564718

NCT01516840

NCT07618988

NCT05573958

NCT02111564

NCT06220123

NCT07195812

NCT03266783

NCT05723510

NCT05750758

NCT04067505

NCT02309411

NCT03522259

NCT06812455

NCT02458729

NCT05960721

NCT01720108

NCT01516814

NCT02047006

NCT02610933

NCT02164578

NCT00439725

NCT02829957

NCT03299296

NCT07077954

NCT02387229

NCT05671276

NCT05794399

NCT04684212

NCT03747081

NCT02367027

NCT05029063

NCT02832544

NCT01830543

NCT03775746

NCT01684423

Known as BAY59-7939 “Comparing the Efficacy and Safety of Rivaroxaban (BAY 59-7939) With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism” NCT00403767
42

“One promising therapeutic option is rivaroxaban (BAY 59-7939, Rivaroxaban), an orally administered direct factor Xa inhibitor” NCT02438098

“Two Strategies of Rivaroxaban [JNJ39039039; BAY-59-7939] and One of Oral Vitamin K Antagonist” NCT01830543

“Rivaroxaban (Xarelto, BAY59-7939) 10 mg tablet administered once daily (od) in the evening.” NCT00362232

“Drug: Xarelto (Rivaroxaban, BAY59-7939)” NCT00973245

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT01507051

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT02504216

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT01442792

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT01853800

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02556203

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00786422

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02367027

“Xarelto (Rivaroxaban, BAY59-7939)” NCT00973323

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02234843

“Rivaroxaban (Xarelto, BAY59-7939)” NCT04720092

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01776424

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01145859

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00439777

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02564718

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01684423

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01516814

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02309411

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00439725

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01516840

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00571649

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02313909

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00440193

“Xarelto (Rivaroxaban, BAY59-7939)” NCT00839163

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00398905

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01674647

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00494871

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00396786

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01839357

“Xarelto (Rivaroxaban, BAY59-7939)” NCT00395772

“Rivaroxaban (Xarelto, BAY59-7939NCT02497716

“Drug: Rivaroxaban (BAY59-7939)” NCT00332020

“Drug: Rivaroxaban (BAY59-7939)” NCT01206972

“Rivaroxaban (BAY59-7939)” NCT00329628

“Rivaroxaban (BAY59-7939)” NCT00402467

“Rivaroxaban (BAY59-7939)” NCT01205932

“Rivaroxaban (BAY59-7939)” NCT00779064

“Rivaroxaban (BAY59-7939)” NCT00361894

NCT02064439

Known as Direct Oral Anticoagulant (DOAC) ClinicalTrials.gov intervention name — accepted as the source's own label NCT05498428
Known as JNJ39039039 “Two Strategies of Rivaroxaban [JNJ39039039; BAY-59-7939] and One of Oral Vitamin K Antagonist” NCT01830543
Known as Rivaroxaban (Xarelto) Rivaroxaban (Xarelto)NCT07011095
2

Rivaroxaban (Xarelto)NCT03465735

Rivaroxaban (Xarelto)NCT01706146

Known as Rivaroxaban accord ChEMBL registry synonym — accepted as the source's own label CHEMBL198362
Known as Rivaroxaban viatris (previously rivaroxaban mylan) ChEMBL registry synonym — accepted as the source's own label CHEMBL198362
Known as Rivaroxabana “Xarelto 15 mg Rivaroxabana 15 mg” NCT05515120
Known as Rovaltro “Rivaroxaban (Rovaltro®) is a novel oral anticoagulant” NCT04569279
Known as Xarelto “Thromboprophylactic regimens Aspirin®(acetylsalicylic acid, AA, Bayer) 300mg/day or Xarelto® (rivaroxaban, factor Xa-inhibitor, Bayer) 10mg/day will be randomly(according to...” NCT02271399
48

“Market approved oral anticoagulation (OAC), such as warfarin (Coumadin), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixiban (Eliquis), edoxaban (Savaysa), or betrixaban (Bevyxxa)” NCT04684212

“A Randomized, Controlled, Phase 2b Study to Evaluate Safety and Efficacy of Rivaroxaban (Xarelto®) for High Risk People With Mild COVID-19” NCT04504032

“Blood concentrations of rivaroxaban (Xarelto, Titusville, New Jersey) at 4 weeks were undetectable in 21% patients from Eastern Europe” PMID 33549557 Feb 2021

“Single administration of oral rivaroxaban in the form of Xarelto® 10mg tablets (Bayer Schering Pharma, Berlin, Germany).” NCT02970773

“Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)” NCT03148457

“novel oral anticoagulant includes 'dabigatran,Pradaxa®', 'rivaroxaban,Xarelto®', and 'apixaban, Eliquis®'.” NCT02504177

“The two most commonly-used anticoagulants will be compared: apixaban (Eliquis) and rivaroxaban (Xarelto).” NCT06953726

“Rivaroxaban (Xarelto, BAY59-7939) 10 mg tablet administered once daily (od) in the evening.” NCT00362232

“a new blood thinner called rivaroxaban (Xarelto) can be used to treat HIT” NCT01598168

“Drug: Xarelto (Rivaroxaban, BAY59-7939)” NCT00973245

“Rivaroxaban 10 MG Oral Tablet [Xarelto]” NCT04994223

“Rivaroxaban 10 MG Oral Tablet [Xarelto]” NCT03522259

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT01507051

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT02504216

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT01442792

“Drug: Rivaroxaban (Xarelto, BAY59-7939)” NCT01853800

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02556203

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00786422

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02234843

“Rivaroxaban (Xarelto, BAY59-7939)” NCT04720092

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01776424

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01145859

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02367027

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02309411

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02564718

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01684423

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00439725

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01516814

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00439777

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01516840

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00571649

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00440193

“Rivaroxaban (Xarelto, BAY59-7939)” NCT02313909

Xarelto (Rivaroxaban, BAY59-7939)” NCT00839163

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00398905

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01674647

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00494871

“Rivaroxaban (Xarelto, BAY59-7939)” NCT01839357

“Rivaroxaban (Xarelto, BAY59-7939)” NCT00396786

Xarelto (Rivaroxaban, BAY59-7939)” NCT00395772

“Rivaroxaban (Xarelto, BAY59-7939” NCT02497716

“Rivaroxaban 2.5 MG [Xarelto]” NCT04838808

“Rivaroxaban 2.5 MG [Xarelto]” NCT05077683

“Rivaroxaban (Xarelto)” NCT02054936

“Rivaroxaban (Xarelto)” NCT06978439

NCT02555111

NCT02422602

NCT00973323

Known as Xarelto is the brand name for rivaroxaban Xarelto is the brand name for rivaroxabanNCT01478282
Action Inhibit “an oral direct inhibitor of factor Xa” PMID 18579811 Jun 2008
Modality Other / unclassified “direct oral anticoagulant” NCT04794569
Route Oral “10 mg of oral rivaroxaban once daily” PMID 18579811 Jun 2008
Target F10 “the direct factor Xa inhibitor rivaroxaban” NCT01812200