drugset / Trial / NCT06449469
The Nordic Aortic Valve Intervention Trial 4 (NOTION-4)
Active not recruiting
352 enrolled
Rigshospitalet, Denmark
Aarhus University Hospital Skejby · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
A randomized clinical trial investigating the incidence and temporal dynamics of subclinical leaflet thickening by cardiac CT in transcatheter bioprosthetic aortic valves in patients randomised to different anti-thrombotic strategies. Additionally, this study aims to examine a possible association between HALT and thromboembolic events.
Timeline
- Start
- 2021-05-01
- Primary completion
- 2026-04-01
- Completion
- 2030-04-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Apixaban | Small molecule | — | Oral |
| Comparator | Aspirin | Small molecule | 75 mg | — |
| Comparator | Clopidogrel | Small molecule | 75 mg | — |
| Background | Dabigatran | Unknown | — | Oral |
| Background | Edoxaban | Small molecule | — | Oral |
| Background | Rivaroxaban | Other / unclassified | — | Oral |
| Background | Warfarin | Small molecule | — | Oral |