drugset / Trial / NCT05006287
The Safety of Non-vitamin K Oral Anticoagulants Compared to Warfarin Early After Cardiac Surgery
RandomizedParallel-groupOpen-labelTreatment
Summary
A small pilot study comparing different blood thinners (non-vitamin K oral anticoagulants \[NOACs\] and warfarin) will be conducted in people at risk for blood clots after open-heart surgery. This study will help us design a much bigger study to test the effectiveness and safety of different blood thinners in people after open-heart surgery. The study will test the following hypotheses: (1) Our standardized use of different blood thinners is feasible in patients early after cardiac surgery. (2) NOACs are safe to use early after cardiac surgery.
Timeline
- Start
- 2022-10-12
- Primary completion
- 2024-05-30
- Completion
- 2024-05-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Apixaban | Small molecule | — | Oral |
| Subject | Dabigatran | Unknown | — | Oral |
| Subject | Edoxaban | Small molecule | — | Oral |
| Subject | Rivaroxaban | Other / unclassified | — | Oral |
| Comparator | Warfarin | Small molecule | — | — |