Effects of Aprepitant/Dexamethasone Versus Mertazepine /Dexamethasone on Postoperative Nausea and Vomiting

Phase 4 Completed 90 enrolled Ain Shams University

RandomizedParallel-groupDouble-blindPrevention

Summary

Laparoscopic sleeve gastrectomy (LSG) is an emerging treatment modality among the various types of surgical approach to obesity (1). The incidence of PONV in obese patients undergoing bariatric surgery, who did not receive antiemetic prophylaxis, is high at nearly 70-80 % (2,3). Postoperatively, bariatric patients appear to suffer from nausea and vomiting more frequently than normal weight or obese patients.

Timeline

Start: 2019-07-15
Primary completion: 2019-12-31
Completion: 2019-12-31

Publications

Ashoor TM, Kassim DY, Esmat IM. A Randomized Controlled Trial for Prevention of Postoperative Nausea and Vomiting after Laparoscopic Sleeve Gastrectomy: Aprepitant/Dexamethasone vs. Mirtazapine/Dexamethasone. Anesthesiol Res Pract. 2022 Apr 30;2022:3541073. doi: 10.1155/2022/3541073. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Aprepitant	Other / unclassified	80 mg	—
Comparator	Mirtazapine	Other / unclassified	30 mg	—
Comparator	Dexamethasone	Small molecule	8 mg	Intravenous

Indications

No indication recorded.