drugset / Trial / NCT04066426

Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain

NCT04066426

Phase 4 Completed 200 enrolled Yuzuncu Yil University
RandomizedParallel-groupTriple-blindTreatment

Summary

Temporomandibular disorders (TMDs) are one of the most common muco-skeletal disorders, seen in the dental clinics. Many factors work together to initiate or aggravate the condition, so it is a multifactorial disorder. The etiology of TMDs may be a result of parafunctional habits such as clenching and bruxism, acute trauma to the jaw, trauma from hyperextension e.g. after a long dental treatment, joint laxity, psychological distress, occlusal disharmony like presence of high crown or free-end saddle leading to joint instability or systemic diseases such as Rheumatoid arthritis or Osteoarthritis. The aim of this study was to evaluate the effects of naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, and naproxen sodium on pain in patients complaining from temporomandibular pain.

Timeline

Start
2018-03-01
Primary completion
2019-04-01
Completion
2019-07-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetaminophen Small molecule
Subject Codeine Small molecule 30 mg
Subject Dexamethasone Small molecule 8 mg
Subject Naproxen Small molecule 550 mg