the Effect of Different Drugs and Infusion Ways on Degree of Postoperative Comfort

Summary

To explore the effect of different drugs and infusion ways on degree of postoperative comfort.Patients undergoing spinal neoplasm surgery receive different patient controlled analgesia(PCA) drugs postoperatively,one group is sufentanil,the other is hydromorphone. Then each drug group will be divided into two subgroups according to the infusion way,intravenously,subcutaneously. During the patient controlled analgesia period, patients' degree of comfort,pain score,sleep quality, the degree of side reaction will be recorded.

Timeline

Start

2019-10-08

Primary completion

2020-09-30

Completion

2020-10-30

Outcome

Met primary endpoint

paper were significantly lower than in SS group PMID 33952398 ↗

paper P < 0.001 PMID 33952398 ↗

Publications

• Wang J, Cui L, Fan L, Wang J. Clinical Effect of Different Drugs and Infusion Techniques for Patient-controlled Analgesia After Spinal Tumor Surgery: A Prospective, Randomized, Controlled Clinical Trial. Clin Ther. 2021 Jun;43(6):1020-1028. doi: 10.1016/j.clinthera.2021.03.019. Epub 2021 May 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	3 ug/kg	Intravenous
Subject	Hydromorphone	Other / unclassified	0.2 mg/kg	Intravenous
Subject	Sufentanil	Other / unclassified	3 ug/kg	Intravenous

Indications

No indication recorded.