Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases

Phase 2 Completed 345 enrolled Cairo University

RandomizedParallel-groupOpen-labelTreatment

Summary

The Efficacy and safety of Preoperative Intravenous Tranexamic acid versus Sublingual misoprostol in reducing blood loss during and after Elective Cesarean section among high risk pregnant cases.

Timeline

Start: 2020-01-20
Primary completion: 2020-12-31
Completion: 2020-12-31

Publications

Dawoud M, Al-Husseiny M, Helal O, Elsherbini M, Abdel-Rasheed M, Sediek M. Intravenous tranexamic acid vs. sublingual misoprostol in high-risk women for postpartum haemorrhage following cesarean delivery; a randomised clinical trial. BMC Pregnancy Childbirth. 2023 Aug 25;23(1):611. doi: 10.1186/s12884-023-05935-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Misoprostol	Other / unclassified	400 ug	Subcutaneous
Comparator	Tranexamic Acid	Small molecule	1 g	Intravenous
Comparator	Oxytocin	Peptide	20 iu	Intravenous

Indications

No indication recorded.