drugset / Trial / NCT04129086
Ketamine for Acute Pain Management After Trauma
RandomizedParallel-groupSingle-blindTreatment
Summary
The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.
Timeline
- Start
- 2020-07-01
- Primary completion
- 2022-03-30
- Completion
- 2022-09-30
Publications
- Klugh JM, Puzio TJ, Wandling MW, Guy-Frank CJ, Green C, Sergot PB, Prater SJ, Balogh J, Stephens CT, Wade CE, Kao LS, Harvin JA. Ketamine for acute pain after trauma: A pragmatic, randomized clinical trial. J Trauma Acute Care Surg. 2024 Oct 1;97(4):514-519. doi: 10.1097/TA.0000000000004325. Epub 2024 May 1.
- Puzio TJ, Klugh J, Wandling MW, Green C, Balogh J, Prater SJ, Stephens CT, Sergot PB, Wade CE, Kao LS, Harvin JA. Ketamine for acute pain after trauma: the KAPT randomized controlled trial. Trials. 2022 Jul 27;23(1):599. doi: 10.1186/s13063-022-06511-6.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketamine | Small molecule | 0.15 mg/kg | Intravenous |
| Comparator | Acetaminophen | Small molecule | 1000 mg | Oral |
| Comparator | Gabapentin | Small molecule | 300 mg | Oral |
| Comparator | Lidocaine | Other / unclassified | — | Topical |
| Comparator | Naproxen | Small molecule | 500 mg | Oral |
Indications
No indication recorded.