drugset / Trial / NCT04150614

BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron

NCT04150614

Phase 4 Recruiting 90 enrolled University of Illinois at Chicago
RandomizedParallel-groupOpen-labelSupportive care

Summary

Patients undergoing either an autologous or allogeneic hematopoietic stem cell transplant (HSCT) and receiving preparative chemotherapy experience a considerable amount of chemotherapy-induced nausea and vomiting (CINV). Current strategies at reducing CINV in this patient population are suboptimal due to lack of efficacy and supportive evidence, potential for increased adverse events, and drug-drug and drug-disease contraindications.

Timeline

Start
2020-05-14
Primary completion
2026-07
Completion
2026-07

Drugs

EvaluationDrugModalityDoseRoute
Comparator Granisetron Other / unclassified Other
Comparator Ondansetron Other / unclassified Intravenous
Comparator Dexamethasone Small molecule Intravenous