drugset / Trial / NCT04166487

Plasma-Adapted First-Line Pembro In NSCLC

NCT04166487 ↗

Phase 2 Active not recruiting 40 enrolled Julia K. Rotow, MD Inivata · collab
Non-randomizedSequentialOpen-labelTreatment

Summary

This research study is studying to see if a blood test, collected at different times during the treatment of metastatic non-small lung cancer, can be used to detect early response in patients being treated with pembrolizumab and use that information to determine whether patients should continue treatment with pembrolizumab or switch treatment to pembrolizumab in combination with chemotherapy. The names of the study drugs involved in this study are: * Pembrolizumab * Platinum doublet chemotherapy, which may include the following: * Carboplatin and pemetrexed * Carboplatin and paclitaxel The name of the blood test: \- InVision (Inivata, Ltd.)

Timeline

Start
2020-01-13
Primary completion
2025-06-01
Completion
2026-12-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Carboplatin Small molecule — Intravenous
Subject Paclitaxel Small molecule — Intravenous
Subject Pembrolizumab Monoclonal antibody — Intravenous
Subject Pemetrexed Small molecule — Intravenous