drugset / Trial / NCT04223219

Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University

NCT04223219

Phase 4 Unknown 90 enrolled Mansoura University
RandomizedParallel-groupTriple-blindTreatment

Summary

Cardiac surgery is associated with post-operative pain which is one of the major problems and remains one of the most controversial issues. Inadequate pain control after cardiac surgery increases the incidence of development of many complications. Intravenous opioids are commonly used for postoperative analgesia either on demand "physician or nurse-controlled" or patient -controlled. Multimodal opioid sparing analgesia has become frequently used, These techniques can be achieved with Dexmedetomidine, low-dose ketamine and magnesium. The study hypotheses that control of perioperative quality of pain with opioid sparing medications may improve analgesia and patient outcome.

Timeline

Start
2019-12-10
Primary completion
2021-08-15
Completion
2021-09-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexmedetomidine Other / unclassified 0.2 ug/kg Intravenous
Comparator Fentanyl Other / unclassified 1 ug/kg
Comparator Fentanyl Other / unclassified 3 ug/kg
Comparator Fentanyl Other / unclassified 20 ug
Comparator Fentanyl Other / unclassified 40 ug
Subject Ketamine Small molecule 2 ug/kg
Subject Magnesium Sulfate Other / unclassified 5 mg/kg
Comparator Propofol Small molecule 2 mg/kg
Comparator Propofol Small molecule 20 mg
Comparator Propofol Small molecule 50 mg
Comparator Propofol Small molecule 100 mg