Minimizing Pain During Office Intradetrussor Botox Injection

Phase 4 Completed 85 enrolled Boston Urogynecology Associates

RandomizedParallel-groupTriple-blindTreatment

Summary

This will be a prospective double-blinded randomized controlled trial comparing two pre-treatment protocols for patients undergoing intradetrussor botox injections to determine if a buffered lidocaine solution offers superior pain control.

Timeline

Start: 2020-08-15
Primary completion: 2023-06-30
Completion: 2023-06-30

Publications

Ward SA, Macharia A, Hacker MR, Elkadry EA, Winkelman WD. A Randomized Controlled Trial of Instillation Protocols Prior to Intradetrusor OnabotulinumtoxinA. Int Urogynecol J. 2025 Apr;36(4):849-855. doi: 10.1007/s00192-025-06080-7. Epub 2025 Mar 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	sodium bicarbonate	Diagnostic / imaging agent	5 ml	Other
Comparator	sodium bicarbonate	Diagnostic / imaging agent	8.4 %	Other
Comparator	Lidocaine	Other / unclassified	1 %	Other
Comparator	Lidocaine	Other / unclassified	50 ml	Other

Minimizing Pain During Office Intradetrussor Botox Injection

Summary

Timeline

Publications

Drugs

Indications