drugset / Trial / NCT04349410

The Fleming [FMTVDM] Directed CoVid-19 Treatment Protocol

NCT04349410

Phase 2/3 Completed 1800 enrolled The Camelot Foundation
RandomizedFactorialSingle-blindTreatment

Summary

Diagnostic determination of disease and treatment responses has been limited to qualitative imaging, measurement of serum markers of disease, and sampling of tissue. In each of these instances, there is a built in error either due to sensitivity and specificity issues, clinician interpretation of results, or acceptance of the use of an indirect marker (blood test) of what is happening elsewhere in the body - at the tissue level. The Fleming Method for Tissue and Vascular Differentiation and Metabolism (FMTVDM) using same state single or sequential quantification comparisons \[1\] provides the first and only patented test (#9566037) - along with the associated submitted patent applications ruled to be covered under #9566037 - that quantitatively measures changes in tissue resulting from inter alia a disease process. This includes inter alia coronary artery disease (CAD), cancer and infectious/inflammatory processes including CoVid-19 pneumonia (CVP) resulting from the metabolic and regional blood flow differences (RBFDs) caused by these diseases. The purpose of this paper is to make clinicians and researchers aware of this proposed method for investigating the prevalence and severity of CVP - in addition to providing rapid determination of treatment response in each patient, directing treatment decisions; thereby reducing the loss of time, money, resources and patient lives.

Timeline

Start
2020-04-11
Primary completion
2020-09-14
Completion
2020-09-14

Drugs

EvaluationDrugModalityDoseRoute
Subject Azithromycin Small molecule 250 mg Intravenous
Subject Clindamycin Unknown 150 mg Oral
Subject Clindamycin Unknown 450 mg Oral
Subject Clindamycin Unknown 4800 mg Oral
Subject Convalescent Serum Unknown 2 unknown Intravenous
Subject Doxycycline Small molecule 100 mg Intravenous
Subject Hydroxychloroquine Small molecule 155 mg Oral
Subject Hydroxychloroquine Small molecule 200 mg Oral
Subject Losartan Other / unclassified 25 mg Oral
Subject Methylprednisolone Other / unclassified 125 mg Intravenous
Subject Primaquine Small molecule 200 mg Oral
Subject Remdesivir Small molecule 100 mg Intravenous
Subject Tocilizumab Monoclonal antibody 8 mg/kg Intravenous
Subject interferon alfa-2b Protein / enzyme biologic 5e+06 iu Inhaled

Indications