Randomized Placebo-controlled Analysis of Superior Laryngeal Nerve Block for Neurogenic Cough

Phase 3 Unknown 65 enrolled University of South Florida

RandomizedParallel-groupSingle-blindTreatment

Summary

Prospective randomized placebo-controlled trial assessing the efficacy of superior laryngeal nerve block for adults with neurogenic cough refractory to proton pump inhibitor as determined by improvement in validated cough severity questionnaires before and after injection of Marcaine and Kenalog compared to placebo (saline injection).

Timeline

Start: 2021-01-12
Primary completion: 2022-12
Completion: 2022-12

Publications

Background Simpson CB, Tibbetts KM, Loochtan MJ, Dominguez LM. Treatment of chronic neurogenic cough with in-office superior laryngeal nerve block. Laryngoscope. 2018 Aug;128(8):1898-1903. doi: 10.1002/lary.27201. Epub 2018 Apr 18.
Background Dhillon VK. Superior laryngeal nerve block for neurogenic cough: A case series. Laryngoscope Investig Otolaryngol. 2019 Jul 5;4(4):410-413. doi: 10.1002/lio2.292. eCollection 2019 Aug.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	0.5 %	Other
Subject	Triamcinolone Acetonide	Other / unclassified	40 mg/ml	Other

Indications

No indication recorded.