Intralesional Steroid Injection Versus Oral Prednisolone in Prevention of Esophageal Stricture

Summary

Endoscopic resection of superficial esophageal neoplasms is already a reality and presents important advantages when compared to esophagectomy as fewer complications and better quality of life. However, extensive resections can lead to difficult-to-manage stenoses. There are several therapies available in order to prevent this stenosis but, to date, there is no definition of the gold standard. The objective of this study was to compare the use of intralesional steroid injection versus oral prednisolone after endoscopic submucosal dissection and to evaluate the stenosis rate, number of dilations to resolve the stenosis and complications.

Timeline

Start

2019-01-21

Primary completion

2021-03-21

Completion

2021-06-21

Publications

• de Oliveira JF, Martins BC, Moura RN, de Paulo GA, Lenz L, de Lima MS, Safatle-Ribeiro AV, Maluf-Filho F. Randomized trial of intralesional steroid injection versus oral prednisolone for preventing esophageal stricture after extensive endoscopic submucosal dissection. Dis Esophagus. 2026 Mar 2;39(2):doag027. doi: 10.1093/dote/doag027.

Drugs

Indications

No indication recorded.