Ketorolac for Moderate to Severe Abdominal Pain in Children

Summary

In children and adolescents (older than 6 years in age) who arrive in the pediatric emergency department because they have been having 5 days or less of abdominal pain (possible appendicitis), will patients who are treated with ketorolac get just as much pain relief as those patients treated with morphine? To answer this research question, we will need a large number of patients in a study. To ensure we have enough patients, we must include many hospitals in different cities and provinces in the same study. Before doing this, though, we must first test a smaller version of the study in our center at McMaster Children's hosptial. The goal of doing this at McMaster first is to make sure or understand: 1. We can enroll enough people in our study over 1 year 2. We can make sure that all the information we collect from patients is complete and nothing is missing 3. Reasons behind why people don't want to participate in the study 4. How satisfied patients and their caregivers were with the study

Timeline

Start

2021-05-05

Primary completion

2023-02-05

Completion

2023-02-06

Publications

• Eltorki M, Busse JW, Freedman SB, Thompson G, Beattie K, Serbanescu C, Carciumaru R, Thabane L, Ali S. Intravenous ketorolac versus morphine in children presenting with suspected appendicitis: a pilot single-centre non-inferiority randomised controlled trial. BMJ Open. 2022 Apr 5;12(4):e056499. doi: 10.1136/bmjopen-2021-056499.

Drugs

Indications