Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients
Summary
The purpose of this study is to determine if a post-operative course of oral dexamethasone affects opioid usage in pediatric patients undergoing tonsillectomy. Patients who are scheduled to undergo tonsillectomy or adenotonsillectomy are randomized to receive either 1) a post-operative steroid course of oral dexamethasone in addition opioids, acetaminophen,NSAIDs or 2) opioids/acetaminophen/NSAIDS alone. All drugs are prescribed per approved FDA labeling. Children between the ages of 4-17 will be considered for enrollment. Participants (or with the aid of parents/legal guardian for subjects unable to complete on their own) will complete a diary twice a day to record pain medication administration and visual pain scale. Remaining steroid and opioid medication will be measured at the routine post-operative appointment that occurs 4 - 6 weeks following surgery.
Timeline
- Start
- 2021-04-14
- Primary completion
- 2023-12-26
- Completion
- 2023-12-26
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexamethasone | Small molecule | 0.5 mg/kg | Oral |
| Background | Acetaminophen | Small molecule | 10 mg/kg | — |
| Background | Acetaminophen | Small molecule | 15 mg/kg | — |
| Background | Ibuprofen | Small molecule | 5 mg/kg | — |
| Background | Ibuprofen | Small molecule | 10 mg/kg | — |
| Background | Oxycodone | Other / unclassified | 0.05 mg/kg | — |
| Background | Oxycodone | Other / unclassified | 0.1 mg/kg | — |