drugset / Trial / NCT04579224

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

NCT04579224

Phase 3 Active not recruiting 184 enrolled National Cancer Institute (NCI)
RandomizedParallel-groupOpen-labelTreatment

Summary

This phase III trial compares the usual chemotherapy treatment to eribulin plus gemcitabine in treating patients with urothelial cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Chemotherapy drugs, such as eribulin, gemcitabine, docetaxel, paclitaxel, and sacituzumab govitecan work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial aims to see whether adding eribulin to standard of care chemotherapy may work better in treating patients with metastatic urothelial cancer.

Timeline

Start
2021-06-28
Primary completion
2030-08-15
Completion
2030-08-15

Drugs

EvaluationDrugModalityDoseRoute
Comparator Docetaxel Small molecule Intravenous
Subject Eribulin Small molecule Intravenous
Subject Gemcitabine Small molecule Intravenous
Comparator Paclitaxel Small molecule Intravenous
Comparator Sacituzumab Govitecan Monoclonal antibody Intravenous