drugset / Trial / NCT04772209
Comparison of Effectiveness and Complications of Catheter Lock Solutions in Non-tunneled Hemodialysis Catheters
Completed
441 enrolled
Zonguldak Ataturk State Hospital
Cumhuriyet University · collabSisli Hamidiye Etfal Training and Research Hospital · collab
RandomizedParallel-groupOpen-labelDiagnostic
Summary
In our study, investigators will investigate the effectiveness and complications of two catheter lock solutions one of which is the standard heparin routinely used in comparison to Sodium bicarbonate. Both solutions were used but not compared head to head. Investigators aim to compare both solutions in terms of catheter lumen patency and their effect on catheter-related infections.
Timeline
- Start
- 2021-02-01
- Primary completion
- 2022-03-30
- Completion
- 2022-03-30
Publications
- Background El-Hennawy AS, Frolova E, Romney WA. Sodium bicarbonate catheter lock solution reduces hemodialysis catheter loss due to catheter-related thrombosis and blood stream infection: an open-label clinical trial. Nephrol Dial Transplant. 2019 Oct 1;34(10):1739-1745. doi: 10.1093/ndt/gfy388.
- Islam M. Sodium bicarbonate is a potential alternative to classic heparin as a lock solution for non-tunneled dialysis catheters: a result from the prospective randomized BicarbLock trial. Int Urol Nephrol. 2024 Apr;56(4):1465-1474. doi: 10.1007/s11255-023-03821-9. Epub 2023 Oct 12.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Heparin | Other / unclassified | — | Other |
| Comparator | sodium bicarbonate | Diagnostic / imaging agent | 8.4 % | Other |