drugset / Trial / NCT04879030
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD
RandomizedParallel-groupOpen-labelTreatment
Summary
The investigators hypothesized that the empirical use of fluoroquinolones together with beta-lactam antibiotics will change their therapeutic success in patients with acute exacerbations of COPD compared to that in patients in whom a single beta-lactam treatment was used. The main goal of this study was to compare the clinical and bacterial success from the use of a combination of beta-lactam and fluoroquinolone antibiotics with that of a single beta-lactam treatment, in adult patients with COPD exacerbations.
Timeline
- Start
- 2020-01-01
- Primary completion
- 2020-08-30
- Completion
- 2020-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ciprofloxacin | Small molecule | — | — |
| Subject | Levofloxacin | Small molecule | — | — |
| Subject | Moxifloxacin | Small molecule | — | — |
| Background | Amoxicillin | Other / unclassified | — | — |
| Background | Cefixime | Other / unclassified | — | — |
| Background | Cefotaxime | Small molecule | — | — |
| Background | Ceftazidime | Small molecule | — | — |
| Background | Ceftriaxone | Other / unclassified | — | — |
| Background | Ertapenem | Small molecule | — | — |
| Background | Meropenem | Small molecule | — | — |
| Background | imipenem-cilastin | Unknown | — | — |
| Background | ticarcillin-clavulanate | Unknown | — | — |