drugset / Trial / NCT04887194
PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates
Non-randomizedSequentialOpen-labelTreatment
Summary
Study 516-010 is an open-label Phase 1, drug-drug interaction and QTc study evaluating the effect of sitravatinib on probe substrates for CYP450 enzymes and BCRP and P-gp transporters.
Timeline
- Start
- 2021-04-08
- Primary completion
- 2022-12-22
- Completion
- 2022-12-22
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dextromethorphan | Unknown | — | — |
| Subject | Digoxin | Other / unclassified | — | — |
| Subject | Midazolam | Small molecule | — | — |
| Subject | Nivolumab | Monoclonal antibody | — | — |
| Subject | Rosuvastatin | Small molecule | — | — |
| Subject | Sitravatinib | Small molecule | — | — |
| Subject | Warfarin | Small molecule | — | — |
Indications
No indication recorded.