drugset / Trial / NCT04949477

Intranasal Dexmedetomidine Versus Oral Paracetamol as a Pre-anaesthetic Medication in Pediatric Age Group

NCT04949477

Phase 2 Completed 86 enrolled Benha University
RandomizedParallel-groupDouble-blindTreatment

Summary

Pre-operative anxiety is a major problem in children because it produces undesired results on induction and postoperative outcome. Dexmedetomidine is a highly specific alpha 2 adrenergic receptor agonist. Studies suggest that Dexmetomidine administration is safe as it is less invasive and have a short half-life. Paracetamol is a potent physical pain killer. It also reduces psychological reactivity and blunts physical and social pain. Adenotonsillectomy is one of the most common surgeries performed in pediatric age groups, so it is important to reduce pre-operative anxiety in those children.

Timeline

Start
2021-07-01
Primary completion
2021-12-01
Completion
2022-01-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 20 mg/kg Oral
Comparator Dexmedetomidine Other / unclassified 1 ug/kg Intranasal

Indications