Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass

Completed 183 enrolled Matthieu Clanet

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Opioid free anesthesia is a recent anesthesia technique with the aim to avoid peroperative use of morphinics to allow a diminution of secondary morphinics effects in the postoperative period. There is no robust data on the real benefits of such procedures. Obese patients are particular at risk of secondary effects of opioids. The aim of our study is to compare opioid free anesthesia to multimodal anesthesia on postoperative morphine consumption after a laparoscopic gastric bypass.

Timeline

Start: 2021-10-05
Primary completion: 2022-09-15
Completion: 2022-10-15

Publications

Clanet M, Touihri K, El Haddad C, Goldsztejn N, Himpens J, Fils JF, Gricourt Y, Van der Linden P, Coeckelenbergh S, Joosten A, Dandrifosse AC. Effect of opioid-free versus opioid-based strategies during multimodal anaesthesia on postoperative morphine consumption after bariatric surgery: a randomised double-blind clinical trial. BJA Open. 2024 Feb 23;9:100263. doi: 10.1016/j.bjao.2024.100263. eCollection 2024 Mar.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.4 ug/kg	—
Subject	Dexmedetomidine	Other / unclassified	0.8 ug/kg	—
Subject	Remifentanil	Small molecule	0.2 ug/kg	—
Subject	Remifentanil	Small molecule	0.4 ug/kg	—

Indications

No indication recorded.