drugset / Trial / NCT05113251

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

NCT05113251

Phase 3 Active not recruiting 927 enrolled AstraZeneca Daiichi Sankyo · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

This study will look at the efficacy and safety of trastuzumab deruxtecan (T-DXd) in a neoadjuvant setting, in high-risk, HER2-positive early non-metastatic breast cancer.

Timeline

Start
2021-10-25
Primary completion
2025-03-12
Completion
2027-04-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Cyclophosphamide Other / unclassified Intravenous
Comparator Doxorubicin Other / unclassified Intravenous
Subject Paclitaxel Small molecule Intravenous
Subject Pertuzumab Monoclonal antibody Intravenous
Subject Trastuzumab Monoclonal antibody Intravenous
Subject Trastuzumab deruxtecan Monoclonal antibody Intravenous