drugset / Trial / NCT05331859
Topical Insulin Versus Autologous Serum After Corneal Surgeries
Non-randomizedParallel-groupDouble-blindTreatment
Summary
The aim of the study is to test whether use of topical insulin or autologous serum eye-drops can promote corneal epithelial healing following photorefractive keratectomy (PRK).
Timeline
- Start
- 2022-05
- Primary completion
- 2022-08
- Completion
- 2022-09
Publications
- Results Diaz-Valle D, Burgos-Blasco B, Rego-Lorca D, Puebla-Garcia V, Perez-Garcia P, Benitez-Del-Castillo JM, Herrero-Vanrell R, Vicario-de-la-Torre M, Gegundez-Fernandez JA. Comparison of the efficacy of topical insulin with autologous serum eye drops in persistent epithelial defects of the cornea. Acta Ophthalmol. 2022 Jun;100(4):e912-e919. doi: 10.1111/aos.14997. Epub 2021 Aug 18.
- Results Diaz-Valle D, Burgos-Blasco B, Gegundez-Fernandez JA, Garcia-Caride S, Puebla-Garcia V, Pena-Urbina P, Benitez-Del-Castillo JM. Topical insulin for refractory persistent corneal epithelial defects. Eur J Ophthalmol. 2021 Sep;31(5):2280-2286. doi: 10.1177/1120672120958307. Epub 2020 Sep 21.
- Results Akcam HT, Unlu M, Karaca EE, Yazici H, Aydin B, Hondur AM. Autologous serum eye-drops and enhanced epithelial healing time after photorefractive keratectomy. Clin Exp Optom. 2018 Jan;101(1):34-37. doi: 10.1111/cxo.12574. Epub 2017 Jul 18.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Autologous serum | Unknown | 20 % | Topical |
| Comparator | Insulin | Protein / enzyme biologic | 1 iu | Topical |
| Comparator | Dexamethasone | Small molecule | 0.1 % | Topical |
| Comparator | Fluorometholone | Other / unclassified | 0.1 % | Topical |
| Comparator | Moxifloxacin | Small molecule | 0.5 % | Topical |