drugset / Trial / NCT05397236

Addition of MgSO4 or Dexamethasone to Bupivacaine on the Prolongation of Ultrasound-guided Quadratus Lumboram Block

NCT05397236

Completed 66 enrolled Ain Shams University
RandomizedParallel-groupDouble-blindPrevention

Summary

The goal of postoperative pain management is the provision of comfort, early mobilization and improved respiratory function without causing inadequate sedation and respiratory compromise, which can be achieved through using regional anethesia. This study aimed to assess the analgesic effect of adding dexamethasone or magnesium sulphate with bupivacaine in ultrasound-guided QLB to prolong its duration in patients undergoing open abdominal surgeries in the early postoperative period regarding pain relief After approval of the ethical committees in Ain Shams University Hospitals, patients undergoing open abdominal surgeries were included in the study, and were divided into three groups (n=22; each); group M, D and group C. In Group A, patients (n=22) received 20 ml bupivacaine 0.25% plus 5 ml of 10% MgSO. In group B, patients (n=22) received 20 ml bupivacaine 0.25% plus 8 mg dexamethasone (2 ml) plus 3 ml 0.9% NaCl. In group C (control), patients (n=22) received 20 ml bupivacaine plus 5 ml 0.9% NaCl.

Timeline

Start
2021-06-01
Primary completion
2022-02-01
Completion
2022-02-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexamethasone Small molecule 2 ml
Comparator Dexamethasone Small molecule 8 mg
Comparator Magnesium Sulfate Other / unclassified 5 ml
Comparator Magnesium Sulfate Other / unclassified 10 %
Comparator Bupivacaine Other / unclassified 0.25 %
Comparator Bupivacaine Other / unclassified 20 ml

Indications

No indication recorded.