Efficacy of Ursodeoxycholic Acid (UDCA) in Patients With Type 2 Diabetes

Summary

The purpose of this study is to evaluate the effects of ursodeoxycholic acid (UDCA) compared to placebo on biomarkers of oxidative stress, inflammation, and endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM) who are treated with metformin but did not meet the target HbA1C \< 7%.

Timeline

Start

2022-09-12

Primary completion

2024-03

Completion

2024-04

Publications

• Lakic B, Skrbic R, Uletilovic S, Mandic-Kovacevic N, Grabez M, Saric MP, Stojiljkovic MP, Soldatovic I, Janjetovic Z, Stokanovic A, Stojakovic N, Mikov M. Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study. J Diabetes Res. 2024 Feb 29;2024:4187796. doi: 10.1155/2024/4187796. eCollection 2024.

Drugs

Indications